Bosutinib | Tocris Bioscience 4361/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Bosutinib

catalog :

4361/10

quantity :

10 mg (also 50 mg)

price :

323 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Levinson N, Boxer S. A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity. Nat Chem Biol. 2014;10:127-32 pubmed publisher
Levinson N, Boxer S. Structural and spectroscopic analysis of the kinase inhibitor bosutinib and an isomer of bosutinib binding to the Abl tyrosine kinase domain. PLoS ONE. 2012;7:e29828 pubmed publisher

product information

brand :

Tocris

master code :

4361

SKU :

4361/10

rank :

0.061

product name :

Bosutinib

description :

Dual Src-Abl inhibitor; antiproliferative

target :

Src Family Kinase Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Bosutinib is a dual inhibitor of Abl and Src kinases (IC50 = 1.2 nM for Src in an enzymatic assay). Displays antiproliferative activity against chronic myelogenous leukemia (CML) cells and decreases the motility and invasion of breast cancer cell lines. Also exhibits potent antiproliferative activity in anchorage-independent, Src-transformed rat fibroblasts (IC50 = 100 nM). Displays selectivity for Src over non-Src family kinases such as growth factor receptor tyrosine kinases.

extended description :

Dual Src-Abl inhibitor; antiproliferative

chemical name text :

4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile

formula :

C 26 H 29 Cl 2 N 5 O 3

formula text :

C26H29Cl2N5O3

cas num :

380843-75-4

USD :

323 USD

product details :

Dual Src-Abl inhibitor; antiproliferative

alt names :

SKI-606

storage :

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage