Lomeguatrib | Tocris Bioscience 4359/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Lomeguatrib

catalog :

4359/10

quantity :

10 mg

price :

278 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

4359

SKU :

4359/10

rank :

0.061

product name :

Lomeguatrib

description :

MGMT inhibitor

target :

Methyltransferase Inhibitors

category :

Small Molecules

sizes available :

10 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Lomeguatrib (LomG) is a potent inhibitor of O 6-methylguanine-DNA methyltransferase (MGMT); (IC50 = 0.009 M in cell-free extracts from HeLa S3 cells); LomG attenuates MGMT activity in vitro and in vivo . LomG enhances the antitumor activity of temozolomide (Cat. No. 2706) in both human melanoma and MCF-7 xenografts. LomG acts as a pseudosubstrate for MGMT and can be used to induce rapid ubiquitin proteasome pathway degradation of proteins that have a MGMT fusion.

extended description :

MGMT inhibitor

chemical name text :

6-[(4-Bromo-2-thienyl)methoxy]-9H-purin-2-amine

formula :

C 10 H 8 BrN 5 OS

formula text :

C10H8BrN5OS

cas num :

192441-08-0

USD :

278 USD

product details :

MGMT inhibitor

alt names :

PaTrin-2

storage :

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage