Axitinib | Tocris Bioscience 4350 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Axitinib

catalog :

4350

quantity :

10 mg (also 50 mg)

price :

259 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Salgado Pabon W, Breshears L, Spaulding A, Merriman J, Stach C, Horswill A, et al. Superantigens are critical for Staphylococcus aureus Infective endocarditis, sepsis, and acute kidney injury. MBio. 2013;4: pubmed publisher
Neelam S, Brooks M, Cammarata P. Lenticular cytoprotection. Part 1: the role of hypoxia inducible factors-1? and -2? and vascular endothelial growth factor in lens epithelial cell survival in hypoxia. Mol Vis. 2013;19:1-15 pubmed
Tseng P, Judy J, Di Carlo D. Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior. Nat Methods. 2012;9:1113-9 pubmed publisher

product information

brand :

Tocris

master code :

4350

SKU :

4350/10

product name :

Axitinib

description :

Potent VEGFR-1, -2 and -3 inhibitor

target :

VEGF Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

386.47

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent inhibitor of VEGFR-2, -3, and -1 (IC50 values are 0.2, 0.1-0.3, and 1.2 nM respectively). Exhibits minimal activity against a panel of ~100 protein kinase. Inhibits angiogenesis and vascular permeability. Also a high affinity BCR-ABL1 (T315I) inhibitor (Ki = 149 pM for autophosphorylated ABL1 (T315I)). Blocks proliferation of Ba/F3 cells expressing BCR-ABL1 (T315I). Orally available.

catalog number base :

4350

product keywords :

Axitinib inhibits VEGFR-1 VEGFR-2 VEGFR-3 inhibitors VEGF receptor receptors vascular endothelial growth factor BCR-ABL VEGFR 4350, VEGFR, VEGF R

extended description :

Potent VEGFR-1, -2 and -3 inhibitor

chemical name text :

N-Methyl-[[3[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-benzamide

formula :

C 22 H 18 N 4 OS

formula text :

C22H18N4OS

cas num :

319460-85-0

2020 USD :

249

2021 USD :

259 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage