Axitinib | Tocris Bioscience 4350/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Axitinib

catalog :

4350/10

quantity :

10 mg (also 50 mg)

price :

327 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Park J, Chae B, Kim M. The Potential of Transforming Growth Factor-beta Inhibitor and Vascular Endothelial Growth Factor Inhibitor as Therapeutic Agents for Uterine Leiomyoma. Int J Med Sci. 2022;19:1779-1786 pubmed publisher
Canavese M, Dottorini T, Crisanti A. VEGF and LPS synergistically silence inflammatory response to Plasmodium berghei infection and protect against cerebral malaria. Pathog Glob Health. 2015;109:255-65 pubmed publisher
Salgado Pabon W, Breshears L, Spaulding A, Merriman J, Stach C, Horswill A, et al. Superantigens are critical for Staphylococcus aureus Infective endocarditis, sepsis, and acute kidney injury. MBio. 2013;4: pubmed publisher
Neelam S, Brooks M, Cammarata P. Lenticular cytoprotection. Part 1: the role of hypoxia inducible factors-1? and -2? and vascular endothelial growth factor in lens epithelial cell survival in hypoxia. Mol Vis. 2013;19:1-15 pubmed
Tseng P, Judy J, Di Carlo D. Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior. Nat Methods. 2012;9:1113-9 pubmed publisher

image

image 1 :

Cat.No. 4350 - Axitinib C22H18N4OS CAS No. 319460-85-0

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4350

SKU :

4350/10

product name :

Axitinib

description :

Potent VEGFR-1, -2 and -3 inhibitor

target :

VEGF Receptor Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at +4°C

observed molecular weight :

386.47

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Axitinib is a potent inhibitor of VEGFR-2, -3, and -1 (IC50 values are 0.2, 0.1-0.3, and 1.2 nM respectively). Axitinib exhibits minimal activity against a panel of ~100 protein kinases. Axitinib inhibits angiogenesis and vascular permeability. Also a high affinity BCR-ABL1 (T315I) inhibitor (Ki = 149 pM for autophosphorylated ABL1 (T315I)). Axitinib blocks proliferation of Ba/F3 cells expressing BCR-ABL1 (T315I). Axitinib (10 mg/kg) decreases T-cell exhaustion and tumor and T-cell hypoxia and improves survival in mice in vivo . Orally available.

product keywords :

Axitinib inhibits VEGFR-1 VEGFR-2 VEGFR-3 inhibitors VEGF receptor receptors vascular endothelial growth factor BCR-ABL VEGFR 4350, VEGFR, VEGF R

extended description :

Potent VEGFR-1, -2 and -3 inhibitor

chemical name text :

N-Methyl-[[3[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-benzamide

formula :

C22H18N4OS

formula text :

C22H18N4OS

cas num :

319460-85-0

USD :

317

USD 2025 :

327 USD

product details :

Potent VEGFR-1, -2 and -3 inhibitor

more info or order :

Tocris Bioscience product webpage