Olanzapine | Tocris Bioscience 4349 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Olanzapine

catalog :

4349

quantity :

10 mg (also 50 mg)

price :

71 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Joshi R, Panicker M. Identifying the In Vivo Cellular Correlates of Antipsychotic Drugs. Eneuro. 2018;5: pubmed publisher
Pérez Gómez A, Carretero M, Weber N, Peterka V, To A, Titova V, et al. A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia. Nat Commun. 2018;9:5272 pubmed publisher
Czysz A, Schappi J, Rasenick M. Lateral diffusion of GÎ±s in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. Neuropsychopharmacology. 2015;40:766-73 pubmed publisher

product information

brand :

Tocris

master code :

4349

SKU :

4349/10

product name :

Olanzapine

description :

5-HT2A antagonist; also D2 antagonist; atypical antipsychotic

target :

Non-selective 5-HT2 Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

312.43

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Antagonist of 5-HT2A and dopamine D2 receptors (Ki values are 4 and 11 nM respectively). Also displays affinity for a range of other receptors including D1 and D4, 5-HT2C, 1, H1 and M1-4 receptors (Ki values range between 1.9 and 31 nM) . Atypical antipsychotic. Displays anticholinergic properties. Also a highly potent activator of hM4Di DREADDs (EC50 values are 5 nM in vitro and 7 nM in vivo ).

catalog number base :

4349

product keywords :

5ht2a 5ht2c serotonergics dopamine dopaminergics d2 antagonists atypical antipsychotics thienobenzodiazepine chemogenetics D2 Receptors DREADDs 5-HT2A Receptors 4349,

extended description :

5-HT2A antagonist; also D2 antagonist; atypical antipsychotic

chemical name text :

2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine

formula :

C 17 H 20 N 4 S

formula text :

C17H20N4S

cas num :

132539-06-1

2020 USD :

2021 USD :

71 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage