UNC 0638 | Tocris Bioscience 4343 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

UNC 0638

catalog :

4343

quantity :

10 mg (also 50 mg)

price :

255 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Bellamy J, Szemes M, Melegh Z, Dallosso A, Kollareddy M, Catchpoole D, et al. Increased Efficacy of Histone Methyltransferase G9a Inhibitors Against MYCN-Amplified Neuroblastoma. Front Oncol. 2020;10:818 pubmed publisher

product information

brand :

Tocris

master code :

4343

SKU :

4343/10

product name :

UNC 0638

description :

Selective G9a and GLP inhibitor

target :

G9a/GLP Inhibitor

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

509.73

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective inhibitor of G9a and GLP histone lysine methyltransferases (IC50 values are 15 nM and 19 nM for G9a and GLP respectively, and 10000 nM for a range of other histone methyltransferases). Potently inhibits dimethylation of H3K9 in MCF-7 cells (IC50 = 70 nM). Restores metabolic and antiviral function in exhausted CD8+ T cells from patients with chronic HCV infection. Cell permeable.

catalog number base :

4343

product keywords :

G9a GLP histone lysine methyltransferases HMTs HMTases epigenetics histone modifications H3K9 H3K9me2 potent selective inhibits inhibitors UNC0638 chronic infection CD8+ T cell exhaustion exhausted Lysine Methyltransferases G9a/GLP 4343,

extended description :

Selective G9a and GLP inhibitor

chemical name text :

2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine

formula :

C 30 H 47 N 5 O 2

formula text :

C30H47N5O2

cas num :

1255580-76-7

2020 USD :

247

2021 USD :

255 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage