UNC 0638 | Tocris Bioscience 4343/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

UNC 0638

catalog :

4343/10

quantity :

10 mg (also 50 mg)

price :

314 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Mabe N, Garcia N, Wolery S, Newcomb R, Meingasner R, Vilona B, et al. G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program. Cell Rep. 2020;33:108341 pubmed publisher
Bellamy J, Szemes M, Melegh Z, Dallosso A, Kollareddy M, Catchpoole D, et al. Increased Efficacy of Histone Methyltransferase G9a Inhibitors Against MYCN-Amplified Neuroblastoma. Front Oncol. 2020;10:818 pubmed publisher
Avgustinova A, Symeonidi A, Castellanos A, Urdiroz Urricelqui U, Solé Boldo L, Martin M, et al. Loss of G9a preserves mutation patterns but increases chromatin accessibility, genomic instability and aggressiveness in skin tumours. Nat Cell Biol. 2018;20:1400-1409 pubmed publisher
Kitajima S, Ivanova E, Guo S, Yoshida R, Campisi M, Sundararaman S, et al. Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer. Cancer Discov. 2019;9:34-45 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4343

SKU :

4343/10

product name :

UNC 0638

description :

Selective G9a and GLP inhibitor

target :

G9a/GLP Inhibitor

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

509.73

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

UNC 0638 is a selective inhibitor of G9a and GLP histone lysine methyltransferases (IC50 values are 15 nM and 19 nM for G9a and GLP respectively, and 10000 nM for a range of other histone methyltransferases). Potently inhibits dimethylation of H3K9 in MCF-7 cells (IC50 = 70 nM). Restores metabolic and antiviral function in exhausted CD8+ T cells from patients with chronic HCV infection. Cell permeable.

product keywords :

G9a GLP histone lysine methyltransferases HMTs HMTases epigenetics histone modifications H3K9 H3K9me2 potent selective inhibits inhibitors UNC0638 chronic infection CD8+ T cell exhaustion exhausted Lysine Methyltransferases G9a/GLP 4343,

extended description :

Selective G9a and GLP inhibitor

chemical name text :

2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine

formula :

C30H47N5O2

formula text :

C30H47N5O2

cas num :

1255580-76-7

USD :

301

USD 2025 :

314 USD

product details :

Selective G9a and GLP inhibitor

more info or order :

Tocris Bioscience product webpage