AMG 21629 | Tocris Bioscience 4330 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AMG 21629

catalog :

4330

quantity :

1 mg

price :

399 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

4330

SKU :

4330/1

product name :

AMG 21629

description :

Potent and selective TRPV1 antagonist

target :

TRPV Antagonists

category :

Small Molecules

unit size :

1 mg

purity :

97%

observed molecular weight :

472.42

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective TRPV1 antagonist. Blocks Ca2+ uptake by CHO cells expressing TRPV1 receptors (IC50 values are 0.6 and 0.8 nM for capsaicin (Cat. No. 0462) and acid-induced Ca2+ uptake, respectively). Exhibits 4000-fold selectivity for TRPV1 over other TRP channels. Blocks capsaicin-induced flinch response and causes hyperthermia in rats. Orally available and non-CNS penetrant.

catalog number base :

4330

product keywords :

AMG21629 transient receptor potential vanilloid TRPV1 antagonists antagonism orally available potent selective hyperthermia TRPV 4330,

extended description :

Potent and selective TRPV1 antagonist

chemical name text :

3-Amino-5-[[2-[(2-methoxyethyl)amino]-6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2(1H)-quinoxalinone

formula :

C 22 H 19 F 3 N 6 O 3

formula text :

C22H19F3N6O3

cas num :

939040-79-6

2020 USD :

387

2021 USD :

399 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage