VU 0360172 hydrochloride | Tocris Bioscience 4323 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VU 0360172 hydrochloride

catalog :

4323

quantity :

10 mg (also 50 mg)

price :

173 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Hanak T, Libbey J, Doty D, Sim J, DePaula Silva A, Fujinami R. Positive modulation of mGluR5 attenuates seizures and reduces TNF-α+ macrophages and microglia in the brain in a murine model of virus-induced temporal lobe epilepsy. Exp Neurol. 2019;311:194-204 pubmed publisher

product information

brand :

Tocris

master code :

4323

SKU :

4323/10

product name :

VU 0360172 hydrochloride

description :

Positive allosteric modulator of mGlu5 receptors

target :

Group I mGluR Modulators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

330.78

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM). Selective for mGlu5; displays no significant activity at mGlu1, mGlu2 or mGlu4 receptors. Exhibits antipsychotic-like activity in a rodent model. Also reduces spontaneous spike and wave discharges without affecting motor behaviour in a rat model of absence epilepsy.

catalog number base :

4323

product keywords :

VU0360172 hydrochloride Positive allosteric modulators mGlu5 mGluR5 mGlur Group I Receptors Glutamate Metabotropic antipsychotic absence epilepsy PAM Glutamate (Metabotropic) Group I Receptors 4323,

extended description :

Positive allosteric modulator of mGlu5 receptors

chemical name text :

N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide hydrochloride

formula :

C 18 H 15 FN 2 O.HCl

formula text :

C18H15FN2O.HCl

cas num :

1309976-62-2

2020 USD :

166

2021 USD :

173 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage