VU 0360172 hydrochloride | Tocris Bioscience 4323/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VU 0360172 hydrochloride

catalog :

4323/10

quantity :

10 mg (also 50 mg)

price :

219 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Bhat S, Henry R, Blanchard A, Stoica B, Loane D, Faden A. Enhanced Akt/GSK-3β/CREB signaling mediates the anti-inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice. J Neurochem. 2021;156:225-248 pubmed publisher
Hanak T, Libbey J, Doty D, Sim J, DePaula Silva A, Fujinami R. Positive modulation of mGluR5 attenuates seizures and reduces TNF-α+ macrophages and microglia in the brain in a murine model of virus-induced temporal lobe epilepsy. Exp Neurol. 2019;311:194-204 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4323

SKU :

4323/10

product name :

VU 0360172 hydrochloride

description :

Positive allosteric modulator of mGlu5 receptors

target :

Group I mGluR Modulators

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

330.78

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

VU 0360172 hydrochloride is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM). Selective for mGlu5; displays no significant activity at mGlu1, mGlu2 or mGlu4 receptors. Exhibits antipsychotic-like activity in a rodent model. Also reduces spontaneous spike and wave discharges without affecting motor behaviour in a rat model of absence epilepsy.

product keywords :

VU0360172 hydrochloride Positive allosteric modulators mGlu5 mGluR5 mGlur Group I Receptors Glutamate Metabotropic antipsychotic absence epilepsy PAM Glutamate (Metabotropic) Group I Receptors 4323,

extended description :

Positive allosteric modulator of mGlu5 receptors

chemical name text :

N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide hydrochloride

formula :

C18H15FN2O.HCl

formula text :

C18H15FN2O.HCl

cas num :

1309976-62-2

USD :

216

USD 2025 :

219 USD

product details :

Positive allosteric modulator of mGlu5 receptors

more info or order :

Tocris Bioscience product webpage