JH 295 | Tocris Bioscience 4322/2 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

JH 295

catalog :

4322/2

quantity :

2 mg

price :

459 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 4322 - JH 295 C18H16N4O2 CAS No. 1311143-71-1

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4322

SKU :

4322/2

product name :

JH 295

description :

Irreversible Nek2 inhibitor

target :

Nek2 Kinase Inhibitors

unit size :

2 mg

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

320.35

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

JH 295 is an irreversible Nek2 inhibitor (IC50=770 nM). Inhibits Nek2 via alkylation of residue Cys22. Displays 5-fold selectivity for Nek2 over Cdk1. Exhibits no significant effect on Aurora B or Plk1 kinases, bipolar spindle assembly or spindle assembly checkpoint. Cell permeable.

product keywords :

JH295 Nek2 inhibitor inhibits irreversible alkylation Nek2 Kinase 4322,

extended description :

Irreversible Nek2 inhibitor

chemical name text :

N-[(3Z)-3-[(2-Ethyl-4-methyl-1H-imidazol-5-yl)methylene]-2,3-dihydro-2-oxo-1H-indol-5-yl]-2-propynamide

formula :

C18H16N4O2

formula text :

C18H16N4O2

cas num :

1311143-71-1

USD :

510

USD 2025 :

459 USD

product details :

Irreversible Nek2 inhibitor

more info or order :

Tocris Bioscience product webpage