BX 795 | Tocris Bioscience 4318 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BX 795

catalog :

4318

quantity :

10 mg (also 50 mg)

price :

227 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Johnson K, Ceglowski J, Roweth H, Forward J, Tippy M, El Husayni S, et al. Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis. Blood Adv. 2019;3:198-211 pubmed publisher
Pillai S, Nguyen J, Johnson J, Haura E, Coppola D, Chellappan S. Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis. Nat Commun. 2015;6:10072 pubmed publisher
Tamguney T, Zhang C, Fiedler D, Shokat K, Stokoe D. Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells. Exp Cell Res. 2008;314:2299-312 pubmed publisher

product information

brand :

Tocris

master code :

4318

SKU :

4318/10

product name :

BX 795

description :

PDPK1 (PDK1) inhibitor

target :

PDK-1 Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

591.47

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of 3-phosphoinositide-dependent kinase 1 (PDPK1). Inhibits Akt phosphorylation at Thr308 in PC3 cells; also inhibits anchorage-independent growth of PC3 and MDA-MB-468 cells. Exhibits activity at other kinases, including TANK-binding kinase 1 (TBK1), Aurora B and I B kinase (IKK ). Also enhances lentiviral transduction of natural killer (NK) cells by around 3.8-fold.

catalog number base :

4318

product keywords :

BX795 pdk1 inhibitors inhibits 3-phosphoinositide-dependent kinase-1 TBK1 TANK-binding kinase 1 Aurora B IkBe IkappaBepsilon I B kinase multi-kinase PDPK1 enhances enhancers viral transduction Phosphoinositide-dependent Kinase 1 PDK1 TANK binding kinase (TBK) Viral Transduction Enhancers 4318,

extended description :

PDPK1 (PDK1) inhibitor

chemical name text :

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide

formula :

C 23 H 26 IN 7 O 2 S

formula text :

C23H26IN7O2S

cas num :

702675-74-9

2020 USD :

218

2021 USD :

227 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage