BX 795 | Tocris Bioscience 4318/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BX 795

catalog :

4318/10

quantity :

10 mg (also 50 mg)

price :

286 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Clapes T, Polyzou A, Prater P, Sagar -, Morales Hernández A, Ferrarini M, et al. Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration. Nat Cell Biol. 2021;23:704-717 pubmed publisher
Johnson K, Ceglowski J, Roweth H, Forward J, Tippy M, El Husayni S, et al. Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis. Blood Adv. 2019;3:198-211 pubmed publisher
Pillai S, Nguyen J, Johnson J, Haura E, Coppola D, Chellappan S. Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis. Nat Commun. 2015;6:10072 pubmed publisher
Tamguney T, Zhang C, Fiedler D, Shokat K, Stokoe D. Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells. Exp Cell Res. 2008;314:2299-312 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4318

SKU :

4318/10

product name :

BX 795

description :

PDPK1 (PDK1) inhibitor

target :

PDK-1 Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

591.47

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BX 795 is an inhibitor of 3-phosphoinositide-dependent kinase 1 (PDPK1). Inhibits Akt phosphorylation at Thr308 in PC3 cells; also inhibits anchorage-independent growth of PC3 and MDA-MB-468 cells. Exhibits activity at other kinases, including TANK-binding kinase 1 (TBK1), Aurora B and I B kinase (IKK ). Also enhances lentiviral transduction of natural killer (NK) cells by around 3.8-fold.

product keywords :

BX795 pdk1 inhibitors inhibits 3-phosphoinositide-dependent kinase-1 TBK1 TANK-binding kinase 1 Aurora B IkBe IkappaBepsilon I B kinase multi-kinase PDPK1 enhances enhancers viral transduction Phosphoinositide-dependent Kinase 1 PDK1 TANK binding kinase (TBK) Viral Transduction Enhancers 4318,

extended description :

PDPK1 (PDK1) inhibitor

chemical name text :

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide

formula :

C23H26IN7O2S

formula text :

C23H26IN7O2S

cas num :

702675-74-9

USD :

283

USD 2025 :

286 USD

product details :

PDPK1 (PDK1) inhibitor

more info or order :

Tocris Bioscience product webpage