JNJ 10397049 | Tocris Bioscience 4317/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

JNJ 10397049

catalog :

4317/10

quantity :

10 mg (also 50 mg)

price :

264 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Mavanji V, Perez Leighton C, Kotz C, Billington C, Parthasarathy S, Sinton C, et al. Promotion of Wakefulness and Energy Expenditure by Orexin-A in the Ventrolateral Preoptic Area. Sleep. 2015;38:1361-70 pubmed publisher

product information

brand :

Tocris

master code :

4317

SKU :

4317/10

rank :

0.061

product name :

JNJ 10397049

description :

Selective OX2 antagonist

target :

OX2 Receptor Antagonists

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

JNJ 10397049 is a selective OX2 receptor antagonist (pIC50 = 7.4 for chimeric OX2 receptors; pKB values are 5.9 and 8.5 for OX1 and OX2 receptors respectively). Shows no significant activity in a panel of over 50 other neurotransmitters and neuropeptide receptors. Achieves high level of OX2 receptor occupancy in the rat brain; exhibits sleep-promoting effects in rats.

extended description :

Selective OX2 antagonist

chemical name text :

N-(2,4-Dibromophenyl)-N -[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]-urea

formula :

C 19 H 20 Br 2 N 2 O 3

formula text :

C19H20Br2N2O3

cas num :

708275-58-5

USD :

264 USD

product details :

Selective OX2 antagonist

storage :

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage