Nigericin sodium salt | Tocris Bioscience 4312/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Nigericin sodium salt

catalog :

4312/10

quantity :

10 mg

price :

100 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Krześniak M, Zajkowicz A, Gdowicz Kłosok A, Głowala Kosińska M, Łasut Szyszka B, Rusin M. Synergistic activation of p53 by actinomycin D and nutlin-3a is associated with the upregulation of crucial regulators and effectors of innate immunity. Cell Signal. 2020;69:109552 pubmed publisher
Platnich J, Chung H, Lau A, Sandall C, Bondzi Simpson A, Chen H, et al. Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome. Cell Rep. 2018;25:1525-1536.e7 pubmed publisher
Ahn H, Kim J, Kang S, Yoon S, Ko H, Kim P, et al. Mercury and arsenic attenuate canonical and non-canonical NLRP3 inflammasome activation. Sci Rep. 2018;8:13659 pubmed publisher
de la Roche M, Hamilton C, Mortensen R, Jeyaprakash A, Ghosh S, Anand P. Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation. J Cell Biol. 2018;217:3560-3576 pubmed publisher
Han B, Ahn H, Lee J, Jeon E, Seo S, Jang K, et al. Nonsaponin fractions of Korean Red Ginseng extracts prime activation of NLRP3 inflammasome. J Ginseng Res. 2017;41:513-523 pubmed publisher
Ahn H, Kang S, Yoon S, Ko H, Kim P, Hong E, et al. Methylene blue inhibits NLRP3, NLRC4, AIM2, and non-canonical inflammasome activation. Sci Rep. 2017;7:12409 pubmed publisher
Ahn H, Jeon E, Kim J, Kang S, Yoon S, Ko H, et al. Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production. Sci Rep. 2017;7:1314 pubmed publisher
Lee J, Ahn H, Hong E, An B, Jeung E, Lee G. Sulforaphane attenuates activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasome. Cell Immunol. 2016;306-307:53-60 pubmed publisher

product information

brand :

Tocris

master code :

4312

SKU :

4312/10

rank :

0.061

product name :

Nigericin sodium salt

description :

Selective K+ ionophore

target :

Ionophores

category :

Small Molecules

sizes available :

10 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Nigericin sodium salt is a potassium ionophore, exchanges K+ for H+ across biological membranes, in a similar manner to Valinomycin (Cat. No. 3373). Stimulates mitochondral ATPase activity and disrupts membrane potential. Also acts as an ionophore for Pb2+ with no activity with other divalent cations. Antibiotic derived from Streptomyces hygroscopius .

extended description :

Selective K+ ionophore

chemical name text :

(2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)- 2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-Hydroxy- 6-(hydroxymethyl)-3,5-dimethyl-2-tetrahydropyranyl]-3-methyl- 2-tetrahydrofuranyl]-5-methyl-2-tetrahydrofuranyl]-9-methoxy- 2,4,10-trimethyl-1,6-dioxaspiro[4

formula :

C 40 H 67 NaO 11

formula text :

C40H67NaO11

cas num :

28643-80-3

USD :

100 USD

product details :

Selective K+ ionophore

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage