ML 7 hydrochloride | Tocris Bioscience 4310/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ML 7 hydrochloride

catalog :

4310/10

quantity :

10 mg (also 50 mg)

price :

146 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Lee H, Stowers R, Chaudhuri O. Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments. Nat Commun. 2019;10:529 pubmed publisher
Tharp K, Kang M, Timblin G, Dempersmier J, Dempsey G, Zushin P, et al. Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues. Cell Metab. 2018;27:602-615.e4 pubmed publisher
Bharadwaj M, Strohmeyer N, Colo G, Helenius J, Beerenwinkel N, Schiller H, et al. αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin. Nat Commun. 2017;8:14348 pubmed publisher
Ets H, Seow C, Moreland R. Sustained Contraction in Vascular Smooth Muscle by Activation of L-type Ca2+ Channels Does Not Involve Ca2+ Sensitization or Caldesmon. Front Pharmacol. 2016;7:516 pubmed publisher
Chaudhuri O, Gu L, Darnell M, Klumpers D, Bencherif S, Weaver J, et al. Substrate stress relaxation regulates cell spreading. Nat Commun. 2015;6:6364 pubmed publisher
Leoni G, Neumann P, Kamaly N, Quirós M, Nishio H, Jones H, et al. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J Clin Invest. 2015;125:1215-27 pubmed publisher
Siddoway B, Altimimi H, Hou H, Petralia R, Xu B, Stellwagen D, et al. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. J Neurosci. 2013;33:11206-11 pubmed publisher

product information

brand :

Tocris

master code :

4310

SKU :

4310/10

rank :

0.061

product name :

ML 7 hydrochloride

description :

Selective inhibitor of myosin light chain kinase

target :

Myosin Light Chain Kinase Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ML 7 hydrochloride is a selective MLCK inhibitor (Ki = 0.3 M). Exhibits more potent inhibition than ML 9 hydrochloride (Cat. No. 0431) Displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. Inhibits proplatelet formation and stabilization.

extended description :

Selective inhibitor of myosin light chain kinase

chemical name text :

Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride

formula :

C 15 H 17 IN 2 O 2 S.HCl

formula text :

C15H17IN2O2S.HCl

cas num :

110448-33-4

USD :

146 USD

product details :

Selective inhibitor of myosin light chain kinase

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage