TPEN | Tocris Bioscience 4309/100 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TPEN

catalog :

4309/100

quantity :

100 mg

price :

143 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Kerns K, Zigo M, Drobnis E, Sutovsky M, Sutovsky P. Zinc ion flux during mammalian sperm capacitation. Nat Commun. 2018;9:2061 pubmed publisher

product information

brand :

Tocris

master code :

4309

SKU :

4309/100

rank :

0.061

product name :

TPEN

description :

Cell-permeable Zn2+ chelator; also inhibits RNA binding protein Lin28

target :

Buffers, Chelators and Reagents

category :

Small Molecules

sizes available :

100 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TPEN is a heavy metal chelator. Reacts with both Zn-proteome and Zn-metallothionein (MT) in LLC-PK1 cells; acts as an intracellular chelator of proteomic Zn2+. Activity decreases intracellular zinc levels, and induces apoptosis in HeLa and cultured human retinal pigment epithelium (RPE) cells. Also inhibits RNA binding protein Lin28 (IC50 = 2.5 M). Cell permeable.

extended description :

Cell-permeable Zn2+ chelator; also inhibits RNA binding protein Lin28

chemical name text :

N,N,N ,N -Tetrakis(2-pyridylmethyl)ethylenediamine

formula :

C 26 H 28 N 6

formula text :

C26H28N6

cas num :

16858-02-9

USD :

143 USD

product details :

Cell-permeable Zn2+ chelator; also inhibits RNA binding protein Lin28

storage :

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage