YC 1 | Tocris Bioscience 4307 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

YC 1

catalog :

4307

quantity :

10 mg (also 50 mg)

price :

212 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Shukla S, Purohit V, Mehla K, Gunda V, Chaika N, Vernucci E, et al. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 2017;32:71-87.e7 pubmed publisher
Bellamy T, Garthwaite J. Pharmacology of the nitric oxide receptor, soluble guanylyl cyclase, in cerebellar cells. Br J Pharmacol. 2002;136:95-103 pubmed

product information

brand :

Tocris

master code :

4307

SKU :

4307/10

product name :

YC 1

description :

Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest

target :

Guanylyl Cyclase Activators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

304.34

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of washed rabbit platelets (IC50 = 14.6 M); induces relaxation in denuded phenylephrine-contracted rabbit aortic rings (EC50 = 1.9 M). Also displays antiproliferative activity in vitro and in vivo by inducing G1 cell cycle arrest in two human hepatocellular carcinoma (HCC) cell lines, and in HCC xenografts in athymic SCID mice. Exhibits low cytotoxicity in non-malignant cells.

catalog number base :

4307

product keywords :

YC1 soluble guanylyl cyclase sGC activators platelet aggregation cGMP antiproliferatives G1 cell cycle arrest inducers p21 CDK2 Guanylyl Cyclase Cell Cycle Inhibitors Enzyme Substrates/ Activators 4307,

extended description :

Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest

chemical name text :

3-(5 -Hydroxymethyl-2 -furyl)-1-benzyl indazole

formula :

C 19 H 16 N 2 O 2

formula text :

C19H16N2O2

cas num :

170632-47-0

2020 USD :

205

2021 USD :

212 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage