INCB 3284 dimesylate | Tocris Bioscience 4306 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

INCB 3284 dimesylate

catalog :

4306

quantity :

10 mg (also 50 mg)

price :

263 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Liu J, Chen S, Wang W, Ning B, Chen F, Shen W, et al. Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-? pathways. Cancer Lett. 2016;379:49-59 pubmed publisher
McMillin M, Frampton G, Thompson M, Galindo C, Standeford H, Whittington E, et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation. 2014;11:121 pubmed publisher
Zhou X, Chen K, Lei H, Sun Z. Klotho gene deficiency causes salt-sensitive hypertension via monocyte chemotactic protein-1/CC chemokine receptor 2-mediated inflammation. J Am Soc Nephrol. 2015;26:121-32 pubmed publisher

product information

brand :

Tocris

master code :

4306

SKU :

4306/10

product name :

INCB 3284 dimesylate

description :

Selective CCR2 antagonist

target :

Chemokine Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

712.76

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, selective hCCR2 antagonist. Exhibits potent antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity (IC50 values are 3.7 and 4.7 nM respectively). Also displays weak hERG activity; inhibits the hERG potassium current (IC50 = 84 M). Orally bioavailable.

catalog number base :

4306

product keywords :

INCB3284 CCR2 antagonist antagonists hCCR2 human chemokine receptor receptors Chemokine CC Receptors 4306,

extended description :

Selective CCR2 antagonist

chemical name text :

N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide dimethanesulfonate

formula :

C 26 H 31 F 3 N 4 O 4 .2CH 4 O 3 S

formula text :

C26H31F3N4O4.2CH4O3S

cas num :

887401-93-6

2020 USD :

255

2021 USD :

263 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage