INCB 3284 dimesylate | Tocris Bioscience 4306/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

INCB 3284 dimesylate

catalog :

4306/10

quantity :

10 mg (also 50 mg)

price :

305 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Liu J, Chen S, Wang W, Ning B, Chen F, Shen W, et al. Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-? pathways. Cancer Lett. 2016;379:49-59 pubmed publisher
McMillin M, Frampton G, Thompson M, Galindo C, Standeford H, Whittington E, et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation. 2014;11:121 pubmed publisher
Zhou X, Chen K, Lei H, Sun Z. Klotho gene deficiency causes salt-sensitive hypertension via monocyte chemotactic protein-1/CC chemokine receptor 2-mediated inflammation. J Am Soc Nephrol. 2015;26:121-32 pubmed publisher

product information

brand :

Tocris

master code :

4306

SKU :

4306/10

rank :

0.061

product name :

INCB 3284 dimesylate

description :

Selective CCR2 antagonist

target :

Chemokine Receptor Antagonists

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

INCB 3284 dimesylate is a potent, selective hCCR2 antagonist. Exhibits potent antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity (IC50 values are 3.7 and 4.7 nM respectively). Also displays weak hERG activity; inhibits the hERG potassium current (IC50 = 84 M). Orally bioavailable.

extended description :

Selective CCR2 antagonist

chemical name text :

N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide dimethanesulfonate

formula :

C 26 H 31 F 3 N 4 O 4 .2CH 4 O 3 S

formula text :

C26H31F3N4O4.2CH4O3S

cas num :

887401-93-6

USD :

305 USD

product details :

Selective CCR2 antagonist

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage