ICA 069673 | Tocris Bioscience 4305 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ICA 069673

catalog :

4305

quantity :

25 mg

price :

386 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Vicente Baz J, Lopez Garcia J, Rivera Arconada I. Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine. Neuropharmacology. 2016;109:131-138 pubmed publisher
Brueggemann L, Haick J, Cribbs L, Byron K. Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol Pharmacol. 2014;86:330-41 pubmed publisher

product information

brand :

Tocris

master code :

4305

SKU :

4305/25

product name :

ICA 069673

description :

KV7.2/KV7.3 channel opener

target :

Voltage-gated Potassium Channel Activators

category :

Small Molecules

unit size :

25 mg

purity :

99%

observed molecular weight :

269.63

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective KV7.2/KV7.3 (KCNQ2/3) channel opener (EC50 = 0.69 M). Exhibits 20-fold selectivity for KV7.2/KV7.3 over KV7.3/KV7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.

catalog number base :

4305

product keywords :

ICA069673 KCNQ2 KCNQ3 kv7.2 kv7.3 channel opener potassium K+ voltage gated potassium channel openers Kv Voltage-Gated Potassium Channels 4305,

extended description :

KV7.2/KV7.3 channel opener

chemical name text :

N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide

formula :

C 11 H 6 ClF 2 N 3 O

formula text :

C11H6ClF2N3O

cas num :

582323-16-8

2020 USD :

374

2021 USD :

386 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage