ICA 069673 | Tocris Bioscience 4305/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ICA 069673

catalog :

4305/5

quantity :

5 mg (also 25 mg)

price :

130 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Radin D, Shifman S, Outhwaite I, Sharma A, Bases R, Seeliger M, et al. Lucanthone, a Potential PPT1 Inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation, and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo. J Pharmacol Exp Ther. 2024;389:51-60 pubmed publisher
Vicente Baz J, Lopez Garcia J, Rivera Arconada I. Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine. Neuropharmacology. 2016;109:131-138 pubmed publisher
Brueggemann L, Haick J, Cribbs L, Byron K. Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol Pharmacol. 2014;86:330-41 pubmed publisher

image

image 1 :

Cat.No. 4305 - ICA 069673 C11H6ClF2N3O CAS No. 582323-16-8

product information

brand :

Tocris

catalog number base :

4305

SKU :

4305/5

product name :

ICA 069673

units size :

5 mg (also 25 mg)

description :

KV7.2/KV7.3 channel opener

target :

Voltage-gated Potassium Channel Activators

category :

Small Molecules

purity :

99%

observed molecular weight :

269.63

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

review stars :

details of functionality :

ICA 069673 is a selective KV7.2/KV7.3 (KCNQ2/3) channel opener (EC50 = 0.69 M). Exhibits 20-fold selectivity for KV7.2/KV7.3 over KV7.3/KV7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.

top caption :

KV7.2/KV7.3 channel opener

extended description :

KV7.2/KV7.3 channel opener

chemical name text :

N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide

formula :

C11H6ClF2N3O

formula text :

C11H6ClF2N3O

cas num :

582323-16-8

USD :

130 USD

product details :

KV7.2/KV7.3 channel opener

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage