ICA 069673 | Tocris Bioscience 4305/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ICA 069673

catalog :

4305/5

quantity :

5 mg (also 25 mg)

price :

130 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Radin D, Shifman S, Outhwaite I, Sharma A, Bases R, Seeliger M, et al. Lucanthone, a Potential PPT1 Inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation, and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo. J Pharmacol Exp Ther. 2024;389:51-60 pubmed publisher
Vicente Baz J, Lopez Garcia J, Rivera Arconada I. Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine. Neuropharmacology. 2016;109:131-138 pubmed publisher
Brueggemann L, Haick J, Cribbs L, Byron K. Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol Pharmacol. 2014;86:330-41 pubmed publisher

image

image 1 :

Cat.No. 4305 - ICA 069673 C11H6ClF2N3O CAS No. 582323-16-8

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4305

SKU :

4305/5

product name :

ICA 069673

description :

KV7.2/KV7.3 channel opener

target :

Voltage-gated Potassium Channel Activators

unit size :

5 mg (also 25 mg)

category :

Small Molecules

purity :

99%

storage :

Store at RT

observed molecular weight :

269.63

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ICA 069673 is a selective KV7.2/KV7.3 (KCNQ2/3) channel opener (EC50 = 0.69 M). Exhibits 20-fold selectivity for KV7.2/KV7.3 over KV7.3/KV7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.

product keywords :

ICA069673 KCNQ2 KCNQ3 kv7.2 kv7.3 channel opener potassium K+ voltage gated potassium channel openers Kv Voltage-Gated Potassium Channels 4305,

extended description :

KV7.2/KV7.3 channel opener

chemical name text :

N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide

formula :

C11H6ClF2N3O

formula text :

C11H6ClF2N3O

cas num :

582323-16-8

USD :

128

USD 2025 :

130 USD

product details :

KV7.2/KV7.3 channel opener

more info or order :

Tocris Bioscience product webpage