iCRT 14 | Tocris Bioscience 4299/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

iCRT 14

catalog :

4299/10

quantity :

10 mg (also 50 mg)

price :

262 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Brown B, Connolly G, Mill C, Williams H, Angelini G, Johnson J, et al. Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells. Aging Cell. 2018;:e12844 pubmed publisher
Volpini X, Ambrosio L, Fozzatti L, Insfrán C, Stempin C, Cervi L, et al. Trypanosoma cruzi Exploits Wnt Signaling Pathway to Promote Its Intracellular Replication in Macrophages. Front Immunol. 2018;9:859 pubmed publisher
Gowda P, Patrick S, Singh A, Sheikh T, Sen E. Mutant Isocitrate Dehydrogenase 1 Disrupts PKM2-β-Catenin-BRG1 Transcriptional Network-Driven CD47 Expression. Mol Cell Biol. 2018;38: pubmed publisher
Kennedy M, Chalamalasetty R, Thomas S, Garriock R, Jailwala P, Yamaguchi T. Sp5 and Sp8 recruit Î²-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription. Proc Natl Acad Sci U S A. 2016;113:3545-50 pubmed publisher
Wu M, Hernandez M, Shen S, Sabo J, Kelkar D, Wang J, et al. Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylation. J Neurosci. 2012;32:6651-64 pubmed publisher

product information

brand :

Tocris

master code :

4299

SKU :

4299/10

rank :

0.061

product name :

iCRT 14

description :

Inhibits -catenin-responsive transcription (CRT)

target :

beta-Catenin Compounds

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

iCRT 14 is a potent inhibitor of -catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between -catenin and TCF4. Induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines. Also acts as transfection enhancer; enhances transgene expression in PC-3 cells by 16 to 35-fold using nonviral systems.

extended description :

Inhibits -catenin-responsive transcription (CRT)

chemical name text :

5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedion

formula :

C 21 H 17 N 3 O 2 S

formula text :

C21H17N3O2S

cas num :

677331-12-3

USD :

262 USD

product details :

Inhibits -catenin-responsive transcription (CRT)

storage :

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage