SMER 28 | Tocris Bioscience 4297 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SMER 28

catalog :

4297

quantity :

50 mg

price :

520 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Puri C, Vicinanza M, Ashkenazi A, Gratian M, Zhang Q, Bento C, et al. The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A. Dev Cell. 2018;45:114-131.e8 pubmed publisher
Lo Cicero A, Jaskowiak A, Egesipe A, Tournois J, Brinon B, Pitrez P, et al. A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells. Sci Rep. 2016;6:34798 pubmed publisher
Zhang M, Lin Y, Sun Y, Zhu S, Zheng J, Liu K, et al. Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation. Cell Stem Cell. 2016;18:653-67 pubmed publisher

product information

brand :

Tocris

master code :

4297

SKU :

4297/50

product name :

SMER 28

description :

Positive regulator of autophagy

target :

Autophagy-related Compounds

category :

Small Molecules

unit size :

50 mg

purity :

99%

observed molecular weight :

264.12

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Positive regulator of autophagy in a mechanism independent from the mTOR pathway. Increases autophagosome synthesis and enhances clearance of model autophagy substrates such as mutant huntingtin and A53T -synuclein, associated with Huntington s and Parkinson s diseases, respectively. Promotes reprogramming of fibroblasts to neural stem-like cells in combination with other chemical reagents.

catalog number base :

4297

product keywords :

SMER28 autophagy inducer induces modulates autophagy MTOR-independent small-molecule enhancers SMERs Autophagy Stem Cell Reprogramming 4297,

extended description :

Positive regulator of autophagy

chemical name text :

6-Bromo-N-2-propenyl-4-quinazolinamine

formula :

C 11 H 10 BrN 3

formula text :

C11H10BrN3

cas num :

307538-42-7

2020 USD :

500

2021 USD :

520 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage