SBE 13 hydrochloride | Tocris Bioscience 4292/50 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SBE 13 hydrochloride

catalog :

4292/50

quantity :

50 mg

price :

445 USD

product information

CHEMISTRY :

ClC(N=C3)=CC=C3COC1=C(OC)C=C(CNCCC2=CC(OC)=C(OC)C=C2)C=C1.Cl

Stock Reference :

4292/50

Cat Number :

4292

Product Name :

SBE 13 hydrochloride

Cas Number :

[1052532-15-6]

Unit Size :

50 mg

Size :

Unit :

USD :

445 USD

Primary Category :

Enzymes

Secondary Category :

Kinases

Tertiary Category :

Polo-like Kinase

Primary Action :

Potent and selective PLK1 inhibitor

Biological Description :

Selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 muM for PLK1, PLK3 and PLK2 respectively). Exhibits no effect on Aurora kinase A activity. Binds and stabilizes the inactive form of PLK1. Delays cell cycle progression, reduces cell proliferation and induces apoptosis in a range of human cancer cell lines. Transiently arrests cells cycle at G0/G1 in primary cells.

Storage :

Desiccate at RT

Formula :

C24H27ClN2O4.HCl

Molwt :

479.4

Minimum Purity :

> 99%

Solubility :

Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO