ISO 1 | Tocris Bioscience 4288/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ISO 1

catalog :

4288/10

quantity :

10 mg (also 50 mg)

price :

263 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Wilson C, Mertens T, Shivshankar P, Bi W, Collum S, Wareing N, et al. Sine oculis homeobox homolog 1 plays a critical role in pulmonary fibrosis. JCI Insight. 2022;7: pubmed publisher
Alban T, Bayık D, Otvos B, Rabljenovic A, Leng L, Jia Shiun L, et al. Glioblastoma Myeloid-Derived Suppressor Cell Subsets Express Differential Macrophage Migration Inhibitory Factor Receptor Profiles That Can Be Targeted to Reduce Immune Suppression. Front Immunol. 2020;11:1191 pubmed publisher
Cotzomi Ortega I, Rosas Cruz A, Ramírez Ramírez D, Reyes Leyva J, Rodriguez Sosa M, Aguilar Alonso P, et al. Autophagy Inhibition Induces the Secretion of Macrophage Migration Inhibitory Factor (MIF) with Autocrine and Paracrine Effects on the Promotion of Malignancy in Breast Cancer. Biology (Basel). 2020;9: pubmed publisher
Rijvers L, Melief M, van der Vuurst de Vries R, Stéphant M, van Langelaar J, Wierenga Wolf A, et al. The macrophage migration inhibitory factor pathway in human B cells is tightly controlled and dysregulated in multiple sclerosis. Eur J Immunol. 2018;48:1861-1871 pubmed publisher
Graham A, Falcone T, Nothnick W. The expression of microRNA-451 in human endometriotic lesions is inversely related to that of macrophage migration inhibitory factor (MIF) and regulates MIF expression and modulation of epithelial cell survival. Hum Reprod. 2015;30:642-52 pubmed publisher

product information

brand :

Tocris

catalog number base :

4288

SKU :

4288/10

product name :

ISO 1

units size :

10 mg (also 50 mg)

description :

Macrophage migration inhibitory factor (MIF) inhibitor

target :

Cytokine Compounds

category :

Small Molecules

purity :

98%

observed molecular weight :

235.24

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ISO 1 is a macrophage migration inhibitory factor (MIF) inhibitor (IC50 = 7 M); inhibits MIF tautomerase activity in vitro and in vivo . Protective against mouse models of streptozotocin -induced diabetes mellitus; blocks anti-inflammatory response following LPS exposure and increases survival. Inhibits airway remodeling in a mouse model of chronic asthma. Cell permeable; orally bioavailable.

top caption :

Macrophage migration inhibitory factor (MIF) inhibitor

extended description :

Macrophage migration inhibitory factor (MIF) inhibitor

chemical name text :

4,5-Dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid methyl ester

formula :

C12H13NO4

formula text :

C12H13NO4

cas num :

478336-92-4

USD :

263 USD

product details :

Macrophage migration inhibitory factor (MIF) inhibitor

storage :

Store at +4Â°C

more info or order :

Tocris Bioscience product webpage