Poly(I:C) | Tocris Bioscience 4287 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Poly(I:C)

catalog :

4287

quantity :

10 mg (also 50 mg)

price :

98 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Tröscher A, Wimmer I, Quemada Garrido L, Köck U, Gessl D, Verberk S, et al. Microglial nodules provide the environment for pathogenic T cells in human encephalitis. Acta Neuropathol. 2019;137:619-635 pubmed publisher
Yu Q, Qu K, Modis Y. Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol Cell. 2018;72:999-1012.e6 pubmed publisher

product information

brand :

Tocris

master code :

4287

SKU :

4287/10

product name :

Poly(I:C)

description :

TLR3 agonist

target :

Toll-like Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Synthetic double-stranded RNA (dsRNA); Toll-like receptor 3 (TLR3) agonist. Aids generation of stable, mature dendritic cells in combination with TLR8 agonist CL 075 . Transfection into NIT-1 cells induces -cell apoptosis. Commonly used to stimulate immune system activation in vivo . Also promotes maturation of hPSC-derived cardiomyocytes. . To prevent denaturation, this product should be reconstituted in solutions with physiological salt concentrations.

catalog number base :

4287

product keywords :

Poly(I:C) immunostimulant toll-like receptor TLR TLR3 agonist inosinic acid cytidylic acid double-stranded RNA dsRNA synthetic maternal immune activation MIA cardiomyocyte differentiation maturation Toll-like Receptors Cardiomyocyte Stem Cells 4287,

extended description :

TLR3 agonist

chemical name text :

Polyinosinic-polycytidylic acid sodium salt

formula :

(C 10 H 13 N 4 O 8 P) x .(C 9 H 14 N 3 O 8 P) x

formula text :

(C10H13N4O8P)x.(C9H14N3O8P)x

cas num :

42424-50-0

2020 USD :

2021 USD :

98 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage