Poly(I:C) | Tocris Bioscience 4287/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Poly(I:C)

catalog :

4287/10

quantity :

10 mg (also 50 mg)

price :

119 USD

more info or order :

Tocris Bioscience product webpage

citations: 20

Reference
D xf6 rschmann P, Seeba C, Thalenhorst T, Roider J, Klettner A. Anti-inflammatory properties of antiangiogenic fucoidan in retinal pigment epithelium cells. Heliyon. 2023;9:e15202 pubmed publisher
Kerner G, Neehus A, Philippot Q, Bohlen J, Rinchai D, Kerrouche N, et al. Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe. Cell Genom. 2023;3:100248 pubmed publisher
Bhagwani A, Ali M, Piper B, Liu M, Hudson J, Kelly N, et al. A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3. iScience. 2023;26:105935 pubmed publisher
Caslin H, Cottam M, Pi xf1 on J, Boney L, Hasty A. Weight cycling induces innate immune memory in adipose tissue macrophages. Front Immunol. 2022;13:984859 pubmed publisher
H xfc bschmann V, Korkut Demirba x15f M, Siegert S. Assessing human iPSC-derived microglia identity and function by immunostaining, phagocytosis, calcium activity, and inflammation assay. STAR Protoc. 2022;3:101866 pubmed publisher
Yap J, Ueda T, Kanemitsu Y, Takeda N, Fukumitsu K, Fukuda S, et al. Human Lung Fibroblasts Exhibit Induced Inflammation Memory via Increased IL6 Gene Expression and Release. Front Immunol. 2022;13:921728 pubmed publisher
Tachibana T, Takahashi M, Khan S, Makino R, Cline M. Poly I:C and R848 facilitate nitric oxide production via inducible nitric oxide synthase in chicks. Comp Biochem Physiol A Mol Integr Physiol. 2022;269:111211 pubmed publisher
Muto T, Guillamot M, Yeung J, Fang J, Bennett J, Nadorp B, et al. TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity. Cell Stem Cell. 2022;29:298-314.e9 pubmed publisher
Meek S, Watson T, Eöry L, McFarlane G, Wynne F, McCleary S, et al. Stem cell-derived porcine macrophages as a new platform for studying host-pathogen interactions. BMC Biol. 2022;20:14 pubmed publisher
Hildebrandt J, K xe4 ckenmeister T, Winkelmann K, D xf6 rschmann P, Roider J, Klettner A. Pro-inflammatory activation changes intracellular transport of bevacizumab in the retinal pigment epithelium in vitro. Graefes Arch Clin Exp Ophthalmol. 2022;260:857-872 pubmed publisher
Stairiker C, Pfister S, Hendrickson E, Yang W, Xie T, Lee C, et al. EZH2 Inhibition Compromises α4-1BB-Mediated Antitumor Efficacy by Reducing the Survival and Effector Programming of CD8+ T Cells. Front Immunol. 2021;12:770080 pubmed publisher
Burns V, Kerppola T. Virus Infection Induces Keap1 Binding to Cytokine Genes, Which Recruits NF-κB p50 and G9a-GLP and Represses Cytokine Transcription. J Immunol. 2021;207:1437-1447 pubmed publisher
Dahal B, Lehman C, Akhrymuk I, Bracci N, Panny L, Barrera M, et al. PERK Is Critical for Alphavirus Nonstructural Protein Translation. Viruses. 2021;13: pubmed publisher
Kothari V, Tang J, He Y, Kramer F, Kanter J, Bornfeldt K. ADAM17 Boosts Cholesterol Efflux and Downstream Effects of High-Density Lipoprotein on Inflammatory Pathways in Macrophages. Arterioscler Thromb Vasc Biol. 2021;41:1854-1873 pubmed publisher
Kunishita Y, Yoshimi R, Kamiyama R, Kishimoto D, Yoshida K, Hashimoto E, et al. TRIM21 Dysfunction Enhances Aberrant B-Cell Differentiation in Autoimmune Pathogenesis. Front Immunol. 2020;11:98 pubmed publisher
Bryche B, Dewaele A, Saint Albin A, Le Poupon Schlegel C, Congar P, Meunier N. IL-17c is involved in olfactory mucosa responses to Poly(I:C) mimicking virus presence. Brain Behav Immun. 2019;79:274-283 pubmed publisher
Tröscher A, Wimmer I, Quemada Garrido L, Köck U, Gessl D, Verberk S, et al. Microglial nodules provide the environment for pathogenic T cells in human encephalitis. Acta Neuropathol. 2019;137:619-635 pubmed publisher
Yu Q, Qu K, Modis Y. Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis. Mol Cell. 2018;72:999-1012.e6 pubmed publisher
Duan L, Zhang X, Miao W, Sun Y, Xiong G, Wu Q, et al. PDGFRβ Cells Rapidly Relay Inflammatory Signal from the Circulatory System to Neurons via Chemokine CCL2. Neuron. 2018;100:183-200.e8 pubmed publisher
Ruiz J, Kanagavelu S, Flores C, Romero L, Riveron R, Shih D, et al. Systemic Activation of TLR3-Dependent TRIF Signaling Confers Host Defense against Gram-Negative Bacteria in the Intestine. Front Cell Infect Microbiol. 2015;5:105 pubmed publisher

image

image 1 :

Cat.No. 7527 - TSA Vivid Fluorophore kit 650

product information

brand :

Tocris

MasterCode :

4287

SKU :

4287/10

product name :

Poly(I:C)

target :

Toll-like Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Poly(I:C) is a synthetic double-stranded RNA (dsRNA); endosomal Toll-like receptor 3 (TLR3) agonist. It also binds to the cytoplasmic receptors, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA-5), elicits the secretion of type I interferon (IFN) and pro-inflammatory cytokines. Poly(I:C) is commonly used for immune system activation in vivo . Poly(I:C) also promotes maturation of hPSC-derived cardiomyocytes by modulating early Notch signaling and cardiomyogenic transcriptional programs. Poly(I:C) promotes generation of stable, mature dendritic cells in combination with TLR8 agonist CL 075 (Cat. No. 6142). Transfection into NIT-1 cells induces -cell apoptosis. . To prevent denaturation, this product should be reconstituted in solutions with physiological salt concentrations.

extended description :

TLR3 agonist

chemical name text :

Polyinosinic-polycytidylic acid sodium salt

formula :

(C 10 H 13 N 4 O 8 P) x .(C 9 H 14 N 3 O 8 P) x

formula text :

(C10H13N4O8P)x.(C9H14N3O8P)x

cas num :

42424-50-0

USD :

119 USD

product details :

TLR3 agonist

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage