HBX 41108 | Tocris Bioscience 4285/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

HBX 41108

catalog :

4285/10

quantity :

10 mg

price :

288 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Ji L, Lu B, Zamponi R, Charlat O, Aversa R, Yang Z, et al. USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin. Nat Commun. 2019;10:4184 pubmed publisher
Tavana O, Sun H, Gu W. Targeting HAUSP in both p53 wildtype and p53-mutant tumors. Cell Cycle. 2018;17:823-828 pubmed publisher
Colland F, Formstecher E, Jacq X, Reverdy C, Planquette C, Conrath S, et al. Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther. 2009;8:2286-95 pubmed publisher

product information

brand :

Tocris

master code :

4285

SKU :

4285/10

rank :

0.071

product name :

HBX 41108

description :

Selective USP7 inhibitor

target :

Deubiquitinating Enzyme Inhibitors

category :

Small Molecules

sizes available :

10 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC50 = 0.8 M). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.

extended description :

Selective USP7 inhibitor

chemical name text :

7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile

formula :

C 13 H 3 ClN 4 O

formula text :

C13H3ClN4O

cas num :

924296-39-9

USD :

288 USD

product details :

Selective USP7 inhibitor

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage