Begacestat | Tocris Bioscience 4283 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Begacestat

catalog :

4283

quantity :

10 mg (also 50 mg)

price :

212 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

4283

SKU :

4283/10

product name :

Begacestat

description :

-secretase inhibitor; lowers A 40 and A 42 levels

target :

Secretase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

391.74

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

-secretase inhibitor; selectively inhibits cleavage of amyloid precursor protein (APP) over Notch. Lowers levels of A 42 and A 40 (EC50 values are 12.4 and 14.8 nM respectively in cells expressing human recombinant APP). Orally active.

catalog number base :

4283

product keywords :

GSI953 Begacestat pfizer gamma gamma-secretase γ g-secretase inhibitors inhibits APP amyloid precursor proteins notch AB40 Abeta40 A 40 AB42 Abeta42 A 42 amyloidbeta amyloidb amyloid GSI-953 Gamma-Secretase Amyloid Beta Peptides 4283,

extended description :

-secretase inhibitor; lowers A 40 and A 42 levels

chemical name text :

5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]-2-thiophenesulfonamide

formula :

C 9 H 8 ClF 6 NO 3 S 2

formula text :

C9H8ClF6NO3S2

cas num :

769169-27-9

2020 USD :

212

2021 USD :

212 USD

alt names :

GSI-953

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage