chemical

WYE 687 dihydrochloride

4282

10 mg (also 50 mg)

278 USD

4282

4282/10

WYE 687 dihydrochloride

Potent and selective mTOR inhibitor

mTOR Inhibitors

Small Molecules

10 mg (also 50 mg)

98%

601.53

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Potent, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) (IC50 = 7 nM). Displays selectivity for mTOR over PI 3-K (~100-fold) and PI 3-K (~500-fold). Inhibits phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt; blocks VEGF secretion and HIF-1 expression. Exhibits antiproliferative effects in cancer cell lines through G1 cell cycle arrest and selective apoptosis.

4282

mTOR WYE687 mammalian target rapamycin inhibitors inhibits ATP competitive potent selective antiproliferatives mTORC1 mTORC2 S6K SGk Akt blocks VEGF secretion HIF-1alpha HIF-1a antiproliferative cell cycle arrest apoptosis mTOR Cell Cycle Inhibitors 4282,

Potent and selective mTOR inhibitor

N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-carbamic acid methyl ester dihydrochloride

C 28 H 32 N 8 O 3 2HCl

C28H32N8O3

1702364-87-1

269

278 USD

Desiccate at RT