WYE 687 dihydrochloride | Tocris Bioscience 4282/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

WYE 687 dihydrochloride

catalog :

4282/10

quantity :

10 mg (also 50 mg)

price :

311 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Saric A, Hipolito V, Kay J, Canton J, Antonescu C, Botelho R. mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells. Mol Biol Cell. 2016;27:321-33 pubmed publisher

image

image 1 :

Cat.No. 4282 - WYE 687 dihydrochloride C28H32N8O3 CAS No. 1702364-87-1

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4282

SKU :

4282/10

product name :

WYE 687 dihydrochloride

description :

Potent and selective mTOR inhibitor

target :

mTOR Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Desiccate at RT

observed molecular weight :

601.53

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

WYE 687 dihydrochloride is a potent, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) (IC50 = 7 nM). Displays selectivity for mTOR over PI 3-K (~100-fold) and PI 3-K (~500-fold). Inhibits phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt; blocks VEGF secretion and HIF-1 expression. Exhibits antiproliferative effects in cancer cell lines through G1 cell cycle arrest and selective apoptosis.

product keywords :

mTOR WYE687 mammalian target rapamycin inhibitors inhibits ATP competitive potent selective antiproliferatives mTORC1 mTORC2 S6K SGk Akt blocks VEGF secretion HIF-1alpha HIF-1a antiproliferative cell cycle arrest apoptosis mTOR Cell Cycle Inhibitors 4282,

extended description :

Potent and selective mTOR inhibitor

chemical name text :

N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-carbamic acid methyl ester dihydrochloride

formula :

C28H32N8O32HCl

formula text :

C28H32N8O3

cas num :

1702364-87-1

USD :

345

USD 2025 :

311 USD

product details :

Potent and selective mTOR inhibitor

more info or order :

Tocris Bioscience product webpage