PF 4800567 hydrochloride | Tocris Bioscience 4281 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 4800567 hydrochloride

catalog :

4281

quantity :

10 mg (also 50 mg)

price :

227 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Oren M, Tarrant A, Alon S, Simon Blecher N, Elbaz I, Appelbaum L, et al. Profiling molecular and behavioral circadian rhythms in the non-symbiotic sea anemone Nematostella vectensis. Sci Rep. 2015;5:11418 pubmed publisher
Cheong J, Zhang F, Chua P, Bay B, Thorburn A, Virshup D. Casein kinase 1Î±-dependent feedback loop controls autophagy in RAS-driven cancers. J Clin Invest. 2015;125:1401-18 pubmed publisher
Zemp I, Wandrey F, Rao S, Ashiono C, Wyler E, Montellese C, et al. CK1? and CK1? are components of human 40S subunit precursors required for cytoplasmic 40S maturation. J Cell Sci. 2014;127:1242-53 pubmed publisher
Zhang L, Hastings M, Green E, Tauber E, Sladek M, Webster S, et al. Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra. Curr Biol. 2013;23:1863-73 pubmed publisher

product information

brand :

Tocris

master code :

4281

SKU :

4281/10

product name :

PF 4800567 hydrochloride

description :

Selective casein kinase 1 inhibitor

target :

Casein Kinase 1 Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

396.27

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective casein kinase 1 inhibitor; displays 22-fold greater potency towards CK1 than CK1 (IC50 values are 32 and 711 nM for CK1 and CK1 respectively). ATP competitive. Displays minimal effect on the circadian clock.

catalog number base :

4281

product keywords :

pfizer selective casein kinase 1 ck1 ck1e ck1epsilon ck1 inhibitors inhibits PF4800567 hydrochloride Casein Kinase 1 4281,

extended description :

Selective casein kinase 1 inhibitor

chemical name text :

3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride

formula :

C 17 H 18 ClN 5 O 2 .HCl

formula text :

C17H18ClN5O2.HCl

cas num :

1391052-28-0

2020 USD :

220

2021 USD :

227 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage