PF 3644022 | Tocris Bioscience 4279 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 3644022

catalog :

4279

quantity :

10 mg

price :

315 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Bouhaddou M, Memon D, Meyer B, White K, Rezelj V, Correa Marrero M, et al. The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell. 2020;182:685-712.e19 pubmed publisher
Tang Y, Tu H, Zhang J, Zhao X, Wang Y, Qin J, et al. K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation. Nat Commun. 2019;10:4157 pubmed publisher
Singh R, Diwan M, Dastidar S, Najmi A. Differential effect of p38 and MK2 kinase inhibitors on the inflammatory and toxicity biomarkers in vitro. Hum Exp Toxicol. 2018;37:521-531 pubmed publisher
Jaco I, Annibaldi A, Lalaoui N, Wilson R, Tenev T, Laurien L, et al. MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death. Mol Cell. 2017;66:698-710.e5 pubmed publisher
Dyve Lingelem A, Hjelseth I, Simm R, Torgersen M, Sandvig K. Geldanamycin Enhances Retrograde Transport of Shiga Toxin in HEp-2 Cells. PLoS ONE. 2015;10:e0129214 pubmed publisher

product information

brand :

Tocris

master code :

4279

SKU :

4279/10

product name :

PF 3644022

description :

Potent MK2 inhibitor

target :

MAPK Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

374.46

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM; Ki = 3 nM). Inhibits tumor necrosis factor (TNF ) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM); exhibits oral efficacy in acute and chronic inflammatory models.

catalog number base :

4279

product keywords :

PF3644022 mapk mitogen-activated protein kinase-activated protein kinase 2 MK-2 MK2 potent anti-inflammatory inhibitors inhibits pfizer MK2 4279,

extended description :

Potent MK2 inhibitor

chemical name text :

(10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5 ,6 :4,5]thieno[3,2-f]quinolin-8-one

formula :

C 21 H 18 N 4 OS

formula text :

C21H18N4OS

cas num :

1276121-88-0

2020 USD :

300

2021 USD :

315 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage