PF 3644022 | Tocris Bioscience 4279/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 3644022

catalog :

4279/10

quantity :

10 mg

price :

400 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Chauhan C, Martinez Val A, Niedenthal R, Olsen J, Kotlyarov A, Bekker Jensen S, et al. PRMT5-mediated regulatory arginine methylation of RIPK3. Cell Death Discov. 2023;9:14 pubmed publisher
Bouhaddou M, Memon D, Meyer B, White K, Rezelj V, Correa Marrero M, et al. The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell. 2020;182:685-712.e19 pubmed publisher
Tang Y, Tu H, Zhang J, Zhao X, Wang Y, Qin J, et al. K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation. Nat Commun. 2019;10:4157 pubmed publisher
Oliva J, Galasinski S, Richey A, Campbell A, Meyers M, Modi N, et al. Clinically advanced p38 inhibitors suppress DUX4 expression in cellular and animal models of facioscapulohumeral muscular dystrophy. J Pharmacol Exp Ther. 2019;: pubmed publisher
McCarthy P, Phair I, Greger C, Pardali K, McGuire V, Clark A, et al. IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3. Immunol Cell Biol. 2019;97:54-71 pubmed publisher
Singh R, Diwan M, Dastidar S, Najmi A. Differential effect of p38 and MK2 kinase inhibitors on the inflammatory and toxicity biomarkers in vitro. Hum Exp Toxicol. 2018;37:521-531 pubmed publisher
Jaco I, Annibaldi A, Lalaoui N, Wilson R, Tenev T, Laurien L, et al. MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death. Mol Cell. 2017;66:698-710.e5 pubmed publisher
Dyve Lingelem A, Hjelseth I, Simm R, Torgersen M, Sandvig K. Geldanamycin Enhances Retrograde Transport of Shiga Toxin in HEp-2 Cells. PLoS ONE. 2015;10:e0129214 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4279

SKU :

4279/10

product name :

PF 3644022

description :

Potent MK2 inhibitor

target :

MAPK Inhibitors

unit size :

10 mg

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

374.46

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PF 3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM; Ki = 3 nM). Inhibits tumor necrosis factor (TNF ) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM); exhibits oral efficacy in acute and chronic inflammatory models.

product keywords :

PF3644022 mapk mitogen-activated protein kinase-activated protein kinase 2 MK-2 MK2 potent anti-inflammatory inhibitors inhibits pfizer MK2 4279,

extended description :

Potent MK2 inhibitor

chemical name text :

(10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5 ,6 :4,5]thieno[3,2-f]quinolin-8-one

formula :

C21H18N4OS

formula text :

C21H18N4OS

cas num :

1276121-88-0

USD :

396

USD 2025 :

400 USD

product details :

Potent MK2 inhibitor

more info or order :

Tocris Bioscience product webpage