product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
PF 431396
catalog :
4278/10
quantity :
10 mg
price :
323 USD
more info or order :
citations: 8
Reference
Brian B, Jolicoeur A, Guerrero C, Nunez M, Sychev Z, Hegre S, et al. Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells. elife. 2019;8: pubmed publisher
Pasquier J, Gosset M, Geyl C, Hoarau Véchot J, Chevrot A, Pocard M, et al. CCL2/CCL5 secreted by the stroma induce IL-6/PYK2 dependent chemoresistance in ovarian cancer. Mol Cancer. 2018;17:47 pubmed publisher
Kotla S, Rao G. Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation. J Biol Chem. 2015;290:30306-20 pubmed publisher
Cheng L, Sullivan B, Retana L, Allen C, Liang H, Locksley R. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. J Exp Med. 2015;212:513-24 pubmed publisher
Chapman N, Yoder A, Barbón K, Bilal M, Connolly S, Houtman J. Proline-rich tyrosine kinase 2 controls PI3-kinase activation downstream of the T cell antigen receptor in human T cells. J Leukoc Biol. 2015;97:285-96 pubmed publisher
Mishra R, Singh S. HIV-1 Tat C phosphorylates VE-cadherin complex and increases human brain microvascular endothelial cell permeability. BMC Neurosci. 2014;15:80 pubmed publisher
Kundumani Sridharan V, Dyukova E, Hansen D, Rao G. 12/15-Lipoxygenase mediates high-fat diet-induced endothelial tight junction disruption and monocyte transmigration: a new role for 15(S)-hydroxyeicosatetraenoic acid in endothelial cell dysfunction. J Biol Chem. 2013;288:15830-42 pubmed publisher
Winter G, Rix U, Carlson S, Gleixner K, Grebien F, Gridling M, et al. Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML. Nat Chem Biol. 2012;8:905-912 pubmed publisher
product information
brand :
Tocris
master code :
4278
SKU :
4278/10
rank :
0.061
product name :
PF 431396
description :
Dual FAK/PYK2 inhibitor
target :
Focal Adhesion Kinase Inhibitors
category :
Small Molecules
sizes available :
10 mg
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats.
extended description :
Dual FAK/PYK2 inhibitor
chemical name text :
N-Methyl-N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide
formula :
C 22 H 21 F 3 N 6 O 3 S
formula text :
C22H21F3N6O3S
cas num :
717906-29-1
USD :
323 USD
product details :
Dual FAK/PYK2 inhibitor
storage :
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK