PF 477736 | Tocris Bioscience 4277 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 477736

catalog :

4277

quantity :

10 mg (also 50 mg)

price :

285 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Meng F, Bhupathi D, Sun J, Liu Q, Ahluwalia D, Wang Y, et al. Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition. BMC Cancer. 2015;15:422 pubmed publisher

product information

brand :

Tocris

master code :

4277

SKU :

4277/10

product name :

PF 477736

description :

Selective Chk1 inhibitor

target :

Checkpoint Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

419.48

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage. Enhances docetaxel (Cat. No. 4056) efficacy in tumor cells and xenografts.

catalog number base :

4277

product keywords :

pfizer PF477736 checkpoint kinases chk1 selective inhibitors inhibits dna damage cell cycle arrest abrogates PF0044736 PF-0044736 Checkpoint Kinases Checkpoint Control Kinases 4277,

extended description :

Selective Chk1 inhibitor

chemical name text :

(R)- -Amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]-cyclohexaneacetamide

formula :

C 22 H 25 N 7 O 2

formula text :

C22H25N7O2

cas num :

952021-60-2

2020 USD :

276

2021 USD :

285 USD

alt names :

PF-0044736

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage