PF 477736 | Tocris Bioscience 4277/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 477736

catalog :

4277/10

quantity :

10 mg (also 50 mg)

price :

319 USD

citations: 4

Reference
Dwivedi V, Pardo Pastor C, Droste R, Kong J, Tucker N, Denning D, et al. Replication stress promotes cell elimination by extrusion. Nature. 2021;593:591-596 pubmed publisher
Sitbon D, Boyarchuk E, Dingli F, Loew D, Almouzni G. Histone variant H3.3 residue S31 is essential for Xenopus gastrulation regardless of the deposition pathway. Nat Commun. 2020;11:1256 pubmed publisher
Liu S, Liu Y, Minami K, Chen A, Wan Q, Yin Y, et al. Inhibiting checkpoint kinase 1 protects bone from bone resorption by mammary tumor in a mouse model. Oncotarget. 2018;9:9364-9378 pubmed publisher
Meng F, Bhupathi D, Sun J, Liu Q, Ahluwalia D, Wang Y, et al. Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition. BMC Cancer. 2015;15:422 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4277

SKU :

4277/10

product name :

PF 477736

description :

Selective Chk1 inhibitor

target :

Checkpoint Kinase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at +4°C

observed molecular weight :

419.48

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PF 477736 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage. Enhances docetaxel (Cat. No. 4056) efficacy in tumor cells and xenografts.

product keywords :

pfizer PF477736 checkpoint kinases chk1 selective inhibitors inhibits dna damage cell cycle arrest abrogates PF0044736 PF-0044736 Checkpoint Kinases Checkpoint Control Kinases 4277,

extended description :

Selective Chk1 inhibitor

chemical name text :

(R)- -Amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]-cyclohexaneacetamide

formula :

C22H25N7O2

formula text :

C22H25N7O2

cas num :

952021-60-2

USD :

354

USD 2025 :

319 USD

product details :

Selective Chk1 inhibitor

alt names :

PF-0044736