AP 24534 | Tocris Bioscience 4274 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AP 24534

catalog :

4274

quantity :

10 mg

price :

278 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Merkulova A, Mitchell S, Stavrou E, Forbes G, Schmaier A. Ponatinib treatment promotes arterial thrombosis and hyperactive platelets. Blood Adv. 2019;3:2312-2316 pubmed publisher
Kim J, Choi S, Lee S, Park K. Voltage-dependent Ca2+ channels promote branching morphogenesis of salivary glands by patterning differential growth. Sci Rep. 2018;8:7566 pubmed publisher
Wong J, Tran L, Magun E, Magun B, Wood L. Production of IL-1? by bone marrow-derived macrophages in response to chemotherapeutic drugs: synergistic effects of doxorubicin and vincristine. Cancer Biol Ther. 2014;15:1395-403 pubmed publisher
Wong J, Smith L, Magun E, Engstrom T, Kelley Howard K, Jandhyala D, et al. Small molecule kinase inhibitors block the ZAK-dependent inflammatory effects of doxorubicin. Cancer Biol Ther. 2013;14:56-63 pubmed publisher

product information

brand :

Tocris

master code :

4274

SKU :

4274/10

product name :

AP 24534

description :

Potent multi-kinase and pan-Bcr-Abl inhibitor

target :

Abl Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

532.56

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent multi-kinase and pan-Bcr-Abl inhibitor. Displays potent activity against cell lines expressing native Bcr-Abl or Bcr-AblT3151 (IC50 values are 0.37 and 2.0 nM respectively); also inhibits other Abl kinase domain mutants at nanomolar potencies. Exhibits inhibitory activity against PDGFR , c-Src and c-Kit (IC50 values are 1.1, 5.4 and 12.5 nM respectively); potently inhibits FGFR and VEGFR family kinases. Orally active. Identified as targeting human host proteins that interact with SARS-CoV-2.

catalog number base :

4274

product keywords :

AP24534 BCR-ABL kinases mutations break point cluster c-abl abelson multikinase inhibitors inhibits vegfr fgfr pdgfralpha pdgfra pdgfr potent Ponatinib COVID-19 SARS-CoV-2 severe acute respiratory syndrome Ponatinib Abl Kinase VEGFR FGFR PDGFR COVID-19 Coronavirus 4274,

extended description :

Potent multi-kinase and pan-Bcr-Abl inhibitor

chemical name text :

3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide

formula :

C 29 H 27 F 3 N 6 O

formula text :

C29H27F3N6O

cas num :

943319-70-8

2020 USD :

267

2021 USD :

278 USD

alt names :

Ponatinib

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage