LRRK2-IN-1 | Tocris Bioscience 4273 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LRRK2-IN-1

catalog :

4273

quantity :

10 mg (also 50 mg)

price :

292 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Bae Y, Joo H, Bae J, Hyeon S, Her S, Ko E, et al. Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage. Cell Death Dis. 2018;9:1125 pubmed publisher
Chen Z, Cao Z, Zhang W, Gu M, Zhou Z, Li B, et al. LRRK2 interacts with ATM and regulates Mdm2-p53 cell proliferation axis in response to genotoxic stress. Hum Mol Genet. 2017;26:4494-4505 pubmed publisher
Chen Z, Zhang W, Chua L, Chai C, Li R, Lin L, et al. Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease. Sci Signal. 2017;10: pubmed publisher
Chia R, Haddock S, Beilina A, Rudenko I, Mamais A, Kaganovich A, et al. Phosphorylation of LRRK2 by casein kinase 1Î± regulates trans-Golgi clustering via differential interaction with ARHGEF7. Nat Commun. 2014;5:5827 pubmed publisher
Saez Atienzar S, Bonet Ponce L, Blesa J, Romero F, Murphy M, Jordan J, et al. The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling. Cell Death Dis. 2014;5:e1368 pubmed publisher
Reynolds A, Doggett E, Riddle S, Lebakken C, Nichols R. LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site status. Front Mol Neurosci. 2014;7:54 pubmed publisher

product information

brand :

Tocris

master code :

4273

SKU :

4273/10

product name :

LRRK2-IN-1

description :

Potent and selective LRRK2 inhibitor

target :

LRRK2 Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

570.09

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2). Inhibits both G2019S mutant and wild-type LRRK2 kinase activity (IC50 values are 6 and 13 nM respectively). Causes dephosphorylation, ubiquitination and degradation of LRRK2. Inhibits IFN- -induced monocyte maturation in vitro .

catalog number base :

4273

product keywords :

parkinsons disease lrrk2 leucine-rich repeat kinase 2 dardarin parkinson s LRRK2 4273, LRRK 2

extended description :

Potent and selective LRRK2 inhibitor

chemical name text :

5,11-Dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one

formula :

C 31 H 38 N 8 O 3

formula text :

C31H38N8O3

cas num :

1234480-84-2

2020 USD :

280

2021 USD :

292 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage