LRRK2-IN-1 | Tocris Bioscience 4273/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LRRK2-IN-1

catalog :

4273/10

quantity :

10 mg (also 50 mg)

price :

367 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Marte A, Russo I, Rebosio C, Valente P, Belluzzi E, Pischedda F, et al. Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. J Neurochem. 2019;150:264-281 pubmed publisher
Bae Y, Joo H, Bae J, Hyeon S, Her S, Ko E, et al. Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage. Cell Death Dis. 2018;9:1125 pubmed publisher
Chen Z, Cao Z, Zhang W, Gu M, Zhou Z, Li B, et al. LRRK2 interacts with ATM and regulates Mdm2-p53 cell proliferation axis in response to genotoxic stress. Hum Mol Genet. 2017;26:4494-4505 pubmed publisher
Park J, Lee J, Cooper S, Broxmeyer H, Cannon J, Kim C. Parkinson disease-associated LRRK2 G2019S transgene disrupts marrow myelopoiesis and peripheral Th17 response. J Leukoc Biol. 2017;102:1093-1102 pubmed publisher
Chen Z, Zhang W, Chua L, Chai C, Li R, Lin L, et al. Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease. Sci Signal. 2017;10: pubmed publisher
Chia R, Haddock S, Beilina A, Rudenko I, Mamais A, Kaganovich A, et al. Phosphorylation of LRRK2 by casein kinase 1Î± regulates trans-Golgi clustering via differential interaction with ARHGEF7. Nat Commun. 2014;5:5827 pubmed publisher
Saez Atienzar S, Bonet Ponce L, Blesa J, Romero F, Murphy M, Jordan J, et al. The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling. Cell Death Dis. 2014;5:e1368 pubmed publisher
Reynolds A, Doggett E, Riddle S, Lebakken C, Nichols R. LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site status. Front Mol Neurosci. 2014;7:54 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

4273

SKU :

4273/10

product name :

LRRK2-IN-1

description :

Potent and selective LRRK2 inhibitor

target :

LRRK2 Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

570.69

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

LRRK2-IN-1 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2). Inhibits both G2019S mutant and wild-type LRRK2 kinase activity (IC50 values are 6 and 13 nM respectively). Causes dephosphorylation, ubiquitination and degradation of LRRK2. Inhibits IFN- -induced monocyte maturation in vitro .

product keywords :

parkinsons disease lrrk2 leucine-rich repeat kinase 2 dardarin parkinson s LRRK2 4273, LRRK 2

extended description :

Potent and selective LRRK2 inhibitor

chemical name text :

5,11-Dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one

formula :

C31H38N8O3

formula text :

C31H38N8O3

cas num :

1234480-84-2

USD :

363

USD 2025 :

367 USD

product details :

Potent and selective LRRK2 inhibitor

more info or order :

Tocris Bioscience product webpage