product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
ML 141
catalog :
4266/10
quantity :
10 mg (also 50 mg)
price :
246 USD
more info or order :
citations: 15
Reference
Li M, Keenan C, Lopez Campos G, Mangum J, Chen Q, Prodanovic D, et al. A Non-canonical Pathway with Potential for Safer Modulation of Transforming Growth Factor-β1 in Steroid-Resistant Airway Diseases. iScience. 2019;12:232-246 pubmed publisher
Pontremoli M, Brioschi M, Baetta R, Ghilardi S, Banfi C. Identification of DKK-1 as a novel mediator of statin effects in human endothelial cells. Sci Rep. 2018;8:16671 pubmed publisher
Thottacherry J, Kosmalska A, Kumar A, Vishen A, Elosegui Artola A, Pradhan S, et al. Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells. Nat Commun. 2018;9:4217 pubmed publisher
Chan Wah Hak L, Khan S, Di Meglio I, Law A, Lucken Ardjomande Häsler S, Quintaneiro L, et al. FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis. Nat Cell Biol. 2018;20:1023-1031 pubmed publisher
Ford C, NANS A, Boucrot E, Hayward R. Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry. PLoS Pathog. 2018;14:e1007051 pubmed publisher
Sepúlveda Ramírez S, Toledo Jacobo L, Henson J, Shuster C. Cdc42 controls primary mesenchyme cell morphogenesis in the sea urchin embryo. Dev Biol. 2018;437:140-151 pubmed publisher
Xing M, Peterman M, Davis R, Oegema K, Shiau A, Field S. GOLPH3 drives cell migration by promoting Golgi reorientation and directional trafficking to the leading edge. Mol Biol Cell. 2016;27:3828-3840 pubmed
El Najjar F, Cifuentes Muñoz N, Chen J, Zhu H, Buchholz U, Moncman C, et al. Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread. PLoS Pathog. 2016;12:e1005922 pubmed publisher
Lomakin A, Lee K, Han S, Bui D, Davidson M, Mogilner A, et al. Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization. Nat Cell Biol. 2015;17:1435-45 pubmed publisher
Mues M, Cheshenko N, Wilson D, Gunther Cummins L, Herold B. Dynasore disrupts trafficking of herpes simplex virus proteins. J Virol. 2015;89:6673-84 pubmed publisher
Sumida G, Yamada S. Rho GTPases and the downstream effectors actin-related protein 2/3 (Arp2/3) complex and myosin II induce membrane fusion at self-contacts. J Biol Chem. 2015;290:3238-47 pubmed publisher
El Sayed F, Camden J, Woods L, Khalafalla M, Petris M, Erb L, et al. P2Y2 nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells. Am J Physiol Cell Physiol. 2014;307:C83-96 pubmed publisher
McNary S, Athanasiou K, Reddi A. Transforming growth factor ?-induced superficial zone protein accumulation in the surface zone of articular cartilage is dependent on the cytoskeleton. Tissue Eng Part A. 2014;20:921-9 pubmed publisher
Wan Q, Cho E, Yokota H, Na S. Rac1 and Cdc42 GTPases regulate shear stress-driven ?-catenin signaling in osteoblasts. Biochem Biophys Res Commun. 2013;433:502-7 pubmed publisher
Tseng P, Judy J, Di Carlo D. Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior. Nat Methods. 2012;9:1113-9 pubmed publisher
product information
brand :
Tocris
master code :
4266
SKU :
4266/10
rank :
0.061
product name :
ML 141
description :
Selective Cdc42 Rho family inhibitor
target :
Rho GTPase Inhibitors
category :
Small Molecules
sizes available :
10 mg (also 50 mg)
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
ML 141 is an allosteric inhibitor of Cdc42 GTPase (EC50 = 2.1 M). Selective for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Inhibits ovarian cancer cell migration in vitro .
extended description :
Selective Cdc42 Rho family inhibitor
chemical name text :
4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide
formula :
C 22 H 21 N 3 O 3 S
formula text :
C22H21N3O3S
cas num :
71203-35-5
USD :
246 USD
product details :
Selective Cdc42 Rho family inhibitor
alt names :
CID 2950007
storage :
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK