AS 1842856 | Tocris Bioscience 4265 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AS 1842856

catalog :

4265

quantity :

10 mg (also 50 mg)

price :

95 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 4265 - AS 1842856 C18H22FN3O3 CAS No. 836620-48-5

product information

brand :

Tocris

master code :

4265

SKU :

4265/10

product name :

AS 1842856

description :

Potent and selective Foxo1 inhibitor; orally bioavailable

target :

Additional Transcription Factor Compounds

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

347.39

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective Foxo1 inhibitor (IC50 values are 33 nM at Foxo1 and 1 M at Foxo3a and Foxo4); decreases Foxo-mediated promoter activity by 70%, 20% and 3% at Foxo1, Foxo4 and Foxo3, respectively. Regulates gluconeogenesis both in vitro and in vivo . Attenuates fasting plasma glucose level in diabetic db/db mice. Also suppresses autophagy, adipocyte differentiation and soluble guanylyl cyclase expression. Also inhibits STAT3 signaling in NSCLC. Orally bioavailable.

catalog number base :

4265

product keywords :

AS1842856 Potent selective FOXO1 inhibitors inhibits gluconeogenesis diabetic diabetes orally bioavailable forkhead box O family soluble guanylyl cyclase autophagy differentiation adipocytes Other Transcription Factors Guanylyl Cyclase Other Differentiation Products Autophagy 4265,

extended description :

Potent and selective Foxo1 inhibitor; orally bioavailable

chemical name text :

5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

formula :

C 18 H 22 FN 3 O 3

formula text :

C18H22FN3O3

cas num :

836620-48-5

2020 USD :

2021 USD :

95 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage