chemical

AS 1842856

4265/10

10 mg (also 50 mg)

122 USD

4265

4265/10

AS 1842856

Potent and selective Foxo1 inhibitor; orally bioavailable

Additional Transcription Factor Compounds

10 mg (also 50 mg)

Small Molecules

98%

Store at -20°C

347.39

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AS 1842856 is a potent and selective Foxo1 inhibitor (IC50 values are 33 nM at Foxo1 and 1 M at Foxo3a and Foxo4); decreases Foxo-mediated promoter activity by 70%, 20% and 3% at Foxo1, Foxo4 and Foxo3, respectively. Regulates gluconeogenesis both in vitro and in vivo . Attenuates fasting plasma glucose level in diabetic db/db mice. Also suppresses autophagy, adipocyte differentiation and soluble guanylyl cyclase expression. Also inhibits STAT3 signaling in NSCLC. Orally bioavailable.

AS1842856 Potent selective FOXO1 inhibitors inhibits gluconeogenesis diabetic diabetes orally bioavailable forkhead box O family soluble guanylyl cyclase autophagy differentiation adipocytes Other Transcription Factors Guanylyl Cyclase Other Differentiation Products Autophagy 4265,

Potent and selective Foxo1 inhibitor; orally bioavailable

5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

C18H22FN3O3

C18H22FN3O3

836620-48-5

120

122 USD

Potent and selective Foxo1 inhibitor; orally bioavailable