Mitoxantrone dihydrochloride | Tocris Bioscience 4250 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Mitoxantrone dihydrochloride

catalog :

4250

quantity :

50 mg

price :

123 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Zhang H, Patel A, Wang Y, Zhang Y, Kathawala R, Qiu L, et al. The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors. Mol Cancer Ther. 2017;16:1021-1030 pubmed publisher
Kathawala R, Wei L, Anreddy N, Chen K, Patel A, Alqahtani S, et al. The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study. Oncotarget. 2015;6:510-21 pubmed

product information

brand :

Tocris

master code :

4250

SKU :

4250/50

product name :

Mitoxantrone dihydrochloride

description :

Topoisomerase II inhibitor; immunosuppressive and antineoplastic agent

target :

DNA Topoisomerase Inhibitors

category :

Small Molecules

unit size :

50 mg

purity :

98%

observed molecular weight :

517.4

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Type II DNA topoisomerase inhibitor. Disrupts DNA synthesis and repair and induces damage by DNA cross-linking. Also inhibits PIM1 kinase (IC50 = 51 nM). Immunomodulatory, antineoplastic and chemotherapeutic agent. Also USP11 inhibitor (IC50= 3.15 M). Induces cell death of pancreatic cancer cell lines expressing wild-type BRCA2 .

catalog number base :

4250

product keywords :

topoisomerase II inhibitors inhibits DNA topoisomerase type II antitumor immunosuppressant DNA synthesis repair PIM1 kinase USP11 ubiquitin specific peptidase 11 chemotherapeutics DNA Topoisomerase Pim Kinase Deubiquitinating Enzymes 4250,

extended description :

Topoisomerase II inhibitor; immunosuppressive and antineoplastic agent

chemical name text :

1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride

formula :

C 22 H 28 N 4 O 6 .2HCl

formula text :

C22H28N4O6.2HCl

cas num :

70476-82-3

2020 USD :

119

2021 USD :

123 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage