A 887826 | Tocris Bioscience 4249 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A 887826

catalog :

4249

quantity :

10 mg (also 50 mg)

price :

221 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Cho Y, Sloutsky R, Naegle K, Cavalli V. Injury-induced HDAC5 nuclear export is essential for axon regeneration. Cell. 2013;155:894-908 pubmed publisher

product information

brand :

Tocris

master code :

4249

SKU :

4249/10

product name :

A 887826

description :

Potent voltage-dependent NaV1.8 channel blocker

target :

Voltage-gated Sodium Channel Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

97%

observed molecular weight :

480.99

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). Reduces tactile allodynia in neuropathic rat models. 3- and 28-fold more potent at NaV1.8 channels compared to NaV1.2 and NaV1.7 channels respectively.

catalog number base :

4249

product keywords :

A887826 sodium channel blocker blocks NaV1.8 voltage-dependent ion channels antiallodynic Voltage-gated Sodium Channels 4249,

extended description :

Potent voltage-dependent NaV1.8 channel blocker

chemical name text :

5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl-3-pyridine carboxamide

formula :

C 26 H 29 ClN 4 O 3

formula text :

C26H29ClN4O3

cas num :

1266212-81-0

2020 USD :

212

2021 USD :

221 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage