product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Torin 2
catalog :
4248/10
quantity :
10 mg (also 50 mg)
price :
250 USD
more info or order :
citations: 16
Reference
Feehan R, Nelson A, Shantz L. Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL. Cell Signal. 2018;52:35-47 pubmed publisher
Harari E, Guo L, Smith S, Paek K, Fernandez R, Sakamoto A, et al. Direct Targeting of the mTOR (Mammalian Target of Rapamycin) Kinase Improves Endothelial Permeability in Drug-Eluting Stents. Arterioscler Thromb Vasc Biol. 2018;: pubmed publisher
Ginzberg M, Chang N, D Souza H, Patel N, Kafri R, Kirschner M. Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity. elife. 2018;7: pubmed publisher
Al Ali H, Ding Y, Slepak T, Wu W, Sun Y, Martinez Y, et al. The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury. J Neurosci. 2017;37:7079-7095 pubmed publisher
Soliman G, Steenson S, Etekpo A. Effects of Metformin and a Mammalian Target of Rapamycin (mTOR) ATP-Competitive Inhibitor on Targeted Metabolomics in Pancreatic Cancer Cell Line. Metabolomics (Los Angel). 2016;6: pubmed publisher
Jennewein L, Ronellenfitsch M, Antonietti P, Ilina E, Jung J, Stadel D, et al. Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas. Oncotarget. 2016;7:20016-32 pubmed publisher
Hussain A, Al Romaizan M, Ahmed M, Thangavel S, Al Dayel F, Beg S, et al. Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of Cisplatin in Epithelial Ovarian Cancer. Mol Med. 2015;21:466-78 pubmed publisher
Yu J, Ramasamy T, Murphy N, Holt M, Czapiewski R, Wei S, et al. PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation. Nat Commun. 2015;6:7212 pubmed publisher
Toops K, Tan L, Jiang Z, Radu R, Lakkaraju A. Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium. Mol Biol Cell. 2015;26:1-14 pubmed publisher
Brown M, Dobrikov M, Gromeier M. Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis. J Virol. 2014;88:13149-60 pubmed publisher
Martin T, Dennis M, Gordon B, Kimball S, Jefferson L. mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading. Am J Physiol Endocrinol Metab. 2014;306:E1397-405 pubmed publisher
Ahmed M, Hussain A, Bavi P, Ahmed S, Al Sobhi S, Al Dayel F, et al. High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma. Carcinogenesis. 2014;35:1564-72 pubmed publisher
Zullo A, Jurcic Smith K, Lee S. Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages. BMC Biochem. 2014;15:4 pubmed publisher
Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, et al. Parallel measurement of dynamic changes in translation rates in single cells. Nat Methods. 2014;11:86-93 pubmed publisher
Hwang J, Jiang T, Kulkarni S, Faure N, Schaffhausen B. Protein phosphatase 2A isoforms utilizing A? scaffolds regulate differentiation through control of Akt protein. J Biol Chem. 2013;288:32064-73 pubmed publisher
Montané M, Menand B. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change. J Exp Bot. 2013;64:4361-74 pubmed publisher
product information
brand :
Tocris
master code :
4248
SKU :
4248/10
rank :
0.061
product name :
Torin 2
description :
Potent and selective mTOR inhibitor
target :
mTOR Inhibitors
category :
Small Molecules
sizes available :
10 mg (also 50 mg)
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively). Activates autophagy. Orally available.
extended description :
Potent and selective mTOR inhibitor
chemical name text :
9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
formula :
C 24 H 15 F 3 N 4 O
formula text :
C24H15F3N4O
cas num :
1223001-51-1
USD :
250 USD
product details :
Potent and selective mTOR inhibitor
storage :
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK