| Reference |
|---|
Sica V, Bravo San Pedro J, Izzo V, Pol J, Pierredon S, Enot D, et al. Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate. Cell Rep. 2019;27:820-834.e9 pubmed publisher |
Neubert P, Weichselbaum A, Reitinger C, Schatz V, Schröder A, Ferdinand J, et al. HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting. Autophagy. 2019;15:1899-1916 pubmed publisher |
Ji J, Petropavlovskaia M, Khatchadourian A, Patapas J, Makhlin J, Rosenberg L, et al. Type 2 diabetes is associated with suppression of autophagy and lipid accumulation in β-cells. J Cell Mol Med. 2019;23:2890-2900 pubmed publisher |
Pyo K, Kim C, Lee M, Kim J, Kim K, Baek S. ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation. Cell Rep. 2018;25:2878-2890.e4 pubmed publisher |
Shi M, Chen B, Mahajan D, Boh B, Zhou Y, Dutta B, et al. Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5. Nat Commun. 2018;9:4987 pubmed publisher |
Kim H, Joe Y, Rah S, Kim S, Park S, Park J, et al. Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury. Cell Death Dis. 2018;9:1060 pubmed publisher |
Li L, Li M, Xu S, Bu W, Zhang M, Gu H, et al. Is Ras a potential target in treatment against cutaneous squamous cell carcinoma?. J Cancer. 2018;9:3373-3381 pubmed publisher |
Napolitano G, Esposito A, Choi H, Matarese M, Benedetti V, Di Malta C, et al. mTOR-dependent phosphorylation controls TFEB nuclear export. Nat Commun. 2018;9:3312 pubmed publisher |
Gubbiotti M, Seifert E, Rodeck U, Hoek J, Iozzo R. Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor decorin. J Biol Chem. 2018;293:16940-16950 pubmed publisher |
Georgilis A, Klotz S, Hanley C, Herranz N, Weirich B, Morancho B, et al. PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells. Cancer Cell. 2018;34:85-102.e9 pubmed publisher |
Barutcu S, Girnius N, Vernia S, Davis R. Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy. Autophagy. 2018;14:1586-1595 pubmed publisher |
Matsui T, Jiang P, Nakano S, Sakamaki Y, Yamamoto H, Mizushima N. Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17. J Cell Biol. 2018;217:2633-2645 pubmed publisher |
Lundquist M, Goncalves M, Loughran R, Possik E, Vijayaraghavan T, Yang A, et al. Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Mol Cell. 2018;70:531-544.e9 pubmed publisher |
Hayama Y, Kimura T, Takeda Y, Nada S, Koyama S, Takamatsu H, et al. Lysosomal Protein Lamtor1 Controls Innate Immune Responses via Nuclear Translocation of Transcription Factor EB. J Immunol. 2018;200:3790-3800 pubmed publisher |
Zuzow N, Ghosh A, Leonard M, Liao J, Yang B, Bennett E. Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches. Mol Biol Cell. 2018;: pubmed publisher |
Tol M, van der Lienden M, Gabriel T, Hagen J, Scheij S, Veenendaal T, et al. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy. 2018;14:437-449 pubmed publisher |
Ha J, Ahn R, Smith H, Sabourin V, Hebert S, Cepeda Cañedo E, et al. Integration of Distinct ShcA Signaling Complexes Promotes Breast Tumor Growth and Tyrosine Kinase Inhibitor Resistance. Mol Cancer Res. 2018;16:894-908 pubmed publisher |
Lambelet M, Terra L, Fukaya M, Meyerovich K, Labriola L, Cardozo A, et al. Dysfunctional autophagy following exposure to pro-inflammatory cytokines contributes to pancreatic β-cell apoptosis. Cell Death Dis. 2018;9:96 pubmed publisher |
Mason J, Wileman T, Chapman T. Lifespan extension without fertility reduction following dietary addition of the autophagy activator Torin1 in Drosophila melanogaster. PLoS ONE. 2018;13:e0190105 pubmed publisher |
Pei G, Buijze H, Liu H, Moura Alves P, Goosmann C, Brinkmann V, et al. The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy. Autophagy. 2017;13:2041-2055 pubmed publisher |
Hung Y, Teragawa C, Kosaisawe N, Gillies T, Pargett M, Minguet M, et al. Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells. elife. 2017;6: pubmed publisher |
Le Guerroué F, Eck F, Jung J, Starzetz T, Mittelbronn M, Kaulich M, et al. Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway. Mol Cell. 2017;68:786-796.e6 pubmed publisher |
Laboucarié T, Detilleux D, Rodriguez Mias R, Faux C, Romeo Y, Franz Wachtel M, et al. TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability. EMBO Rep. 2017;18:2197-2218 pubmed publisher |
Hong Z, Pedersen N, Wang L, Torgersen M, Stenmark H, Raiborg C. PtdIns3P controls mTORC1 signaling through lysosomal positioning. J Cell Biol. 2017;216:4217-4233 pubmed publisher |
Cooper J, Ou Y, McMillan E, Vaden R, Zaman A, Bodemann B, et al. TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer. Cancer Res. 2017;77:5077-5094 pubmed publisher |
Nguyen T, Louie S, Daniele J, Tran Q, Dillin A, Zoncu R, et al. DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy. Dev Cell. 2017;42:9-21.e5 pubmed publisher |
Gupta A, Anjomani Virmouni S, Koundouros N, Dimitriadi M, Choo Wing R, Valle A, et al. PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation. Mol Cell. 2017;65:999-1013.e7 pubmed publisher |
Schwartz J, Clayton K, Mujib S, Zhang H, Rahman A, Liu J, et al. Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9. J Immunol. 2017;198:3181-3194 pubmed publisher |
Yuan H, Tan B, Gao S. Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017;8:e2608 pubmed publisher |
Li Z, Schulze R, Weller S, Krueger E, Schott M, Zhang X, et al. A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets. Sci Adv. 2016;2:e1601470 pubmed publisher |
Torgersen M, Klokk T, Kavaliauskiene S, Klose C, Simons K, Skotland T, et al. The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport. Oncotarget. 2016;7:86871-86888 pubmed publisher |
Sobol A, Askonas C, Alani S, Weber M, Ananthanarayanan V, Osipo C, et al. Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth and Proliferation. Mol Cancer Res. 2017;15:117-127 pubmed publisher |
Pai G, Zielinski A, Koalick D, Ludwig K, Wang Z, Borgmann K, et al. TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress. Oncotarget. 2016;7:85365-85380 pubmed publisher |
Sinha R, Singh B, Zhou J, Xie S, Farah B, Lesmana R, et al. Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells. Autophagy. 2017;13:169-186 pubmed publisher |
Kottakis F, Nicolay B, Roumane A, Karnik R, Gu H, Nagle J, et al. LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature. 2016;539:390-395 pubmed publisher |
Bayraktar O, Oral O, Kocaturk N, Akkoç Y, Eberhart K, Kosar A, et al. IBMPFD Disease-Causing Mutant VCP/p97 Proteins Are Targets of Autophagic-Lysosomal Degradation. PLoS ONE. 2016;11:e0164864 pubmed publisher |
Kimura T, Nada S, Takegahara N, Okuno T, Nojima S, Kang S, et al. Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals. Nat Commun. 2016;7:13130 pubmed publisher |
Mao Y, van Hoef V, Zhang X, Wennerberg E, Lorent J, Witt K, et al. IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells. Blood. 2016;128:1475-89 pubmed publisher |
Fernández B, Fdez E, Gomez Suaga P, Gil F, Molina Villalba I, Ferrer I, et al. Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A. Autophagy. 2016;12:1487-506 pubmed publisher |
Holler C, Taylor G, McEachin Z, Deng Q, Watkins W, Hudson K, et al. Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia. Mol Neurodegener. 2016;11:46 pubmed publisher |
Liu B, Qian S. Characterizing inactive ribosomes in translational profiling. Translation (Austin). 2016;4:e1138018 pubmed publisher |
Chen X, Li M, Li L, Xu S, Huang D, Ju M, et al. Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway. Sci Rep. 2016;6:28423 pubmed publisher |
Erbil S, Oral O, Mitou G, Kig C, Durmaz Timucin E, Guven Maiorov E, et al. RACK1 Is an Interaction Partner of ATG5 and a Novel Regulator of Autophagy. J Biol Chem. 2016;291:16753-65 pubmed publisher |
Choi H, Merceron C, Mangiavini L, Seifert E, Schipani E, Shapiro I, et al. Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Autophagy. 2016;12:1631-46 pubmed publisher |
Kobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, et al. Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis. J Immunol. 2016;197:504-16 pubmed publisher |
Hao Y, Frey E, Yoon C, Wong H, Nestorovski D, Holzman L, et al. An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK. elife. 2016;5: pubmed publisher |
Ma N, Ma Y, Nakashima A, Kikkawa U, Furuyashiki T. The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission Yeast. PLoS ONE. 2016;11:e0156239 pubmed publisher |
Xu Y, Wan W, Shou X, Huang R, You Z, Shou Y, et al. TP53INP2/DOR, a mediator of cell autophagy, promotes rDNA transcription via facilitating the assembly of the POLR1/RNA polymerase I preinitiation complex at rDNA promoters. Autophagy. 2016;12:1118-28 pubmed publisher |
Pastore N, Brady O, Diab H, Martina J, Sun L, Huynh T, et al. TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages. Autophagy. 2016;12:1240-58 pubmed publisher |
Zhang J, Lachance V, Schaffner A, Li X, Fedick A, Kaye L, et al. A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects. PLoS Genet. 2016;12:e1005848 pubmed publisher |
Gandin V, Masvidal L, Cargnello M, Gyenis L, McLaughlan S, Cai Y, et al. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Nat Commun. 2016;7:11127 pubmed publisher |
Gandin V, Masvidal L, Hulea L, Gravel S, Cargnello M, McLaughlan S, et al. nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs. Genome Res. 2016;26:636-48 pubmed publisher |
Jennewein L, Ronellenfitsch M, Antonietti P, Ilina E, Jung J, Stadel D, et al. Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas. Oncotarget. 2016;7:20016-32 pubmed publisher |
Pema M, Drusian L, Chiaravalli M, Castelli M, Yao Q, Ricciardi S, et al. mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex. Nat Commun. 2016;7:10786 pubmed publisher |
Puente C, Hendrickson R, Jiang X. Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy. J Biol Chem. 2016;291:6026-35 pubmed publisher |
Bouché V, Espinosa A, Leone L, Sardiello M, Ballabio A, Botas J. Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway. Autophagy. 2016;12:484-98 pubmed publisher |
Xia Q, Wang H, Hao Z, Fu C, Hu Q, Gao F, et al. TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion. EMBO J. 2016;35:121-42 pubmed publisher |
Ma Y, Ma N, Liu Q, Qi Y, Manabe R, Furuyashiki T. Tor Signaling Regulates Transcription of Amino Acid Permeases through a GATA Transcription Factor Gaf1 in Fission Yeast. PLoS ONE. 2015;10:e0144677 pubmed publisher |
Contreras P, Gonzalez Zuñiga M, González Hódar L, Yáñez M, Dulcey A, Marugan J, et al. Neuronal gene repression in Niemann-Pick type C models is mediated by the c-Abl/HDAC2 signaling pathway. Biochim Biophys Acta. 2016;1859:269-79 pubmed publisher |
Saric A, Hipolito V, Kay J, Canton J, Antonescu C, Botelho R. mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells. Mol Biol Cell. 2016;27:321-33 pubmed publisher |
Grassi G, Di Caprio G, Santangelo L, Fimia G, Cozzolino A, Komatsu M, et al. Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation. Cell Death Dis. 2015;6:e1880 pubmed publisher |
Gubbiotti M, Neill T, Frey H, Schaefer L, Iozzo R. Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy. Matrix Biol. 2015;48:14-25 pubmed publisher |
Wong P, Feng Y, Wang J, Shi R, Jiang X. Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A. Nat Commun. 2015;6:8048 pubmed publisher |
Torres Ayuso P, Tello Lafoz M, Mérida I, Ãvila Flores A. Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1. Oncogenesis. 2015;4:e164 pubmed publisher |
Newton P, Vuppalapati K, Bouderlique T, Chagin A. Pharmacological inhibition of lysosomes activates the MTORC1 signaling pathway in chondrocytes in an autophagy-independent manner. Autophagy. 2015;11:1594-607 pubmed publisher |
Avey D, Tepper S, Li W, Turpin Z, ZHU F. Phosphoproteomic Analysis of KSHV-Infected Cells Reveals Roles of ORF45-Activated RSK during Lytic Replication. PLoS Pathog. 2015;11:e1004993 pubmed publisher |
Moon J, Hisata S, Park M, DeNicola G, Ryter S, Nakahira K, et al. mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation. Cell Rep. 2015;12:102-115 pubmed publisher |
Matsuzawa Y, Oshima S, Takahara M, Maeyashiki C, Nemoto Y, Kobayashi M, et al. TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. Autophagy. 2015;11:1052-62 pubmed publisher |
Ricoult S, Yecies J, Ben Sahra I, Manning B. Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP. Oncogene. 2016;35:1250-60 pubmed publisher |
Jung J, Genau H, Behrends C. Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9. Mol Cell Biol. 2015;35:2479-94 pubmed publisher |
Saqcena M, Patel D, Menon D, Mukhopadhyay S, Foster D. Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle. Cell Cycle. 2015;14:2285-92 pubmed publisher |
Fonseca B, Zakaria C, Jia J, Graber T, Svitkin Y, Tahmasebi S, et al. La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1). J Biol Chem. 2015;290:15996-6020 pubmed publisher |
Chung J, Bauer D, Ghamari A, Nizzi C, Deck K, Kingsley P, et al. The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Sci Signal. 2015;8:ra34 pubmed publisher |
Sciarretta S, Zhai P, Maejima Y, Del Re D, Nagarajan N, Yee D, et al. mTORC2 regulates cardiac response to stress by inhibiting MST1. Cell Rep. 2015;11:125-36 pubmed publisher |
Shi Y, Chen J, Karner C, Long F. Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation. Proc Natl Acad Sci U S A. 2015;112:4678-83 pubmed publisher |
Speranza L, Giuliano T, Volpicelli F, De Stefano M, Lombardi L, Chambery A, et al. Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. Front Behav Neurosci. 2015;9:62 pubmed publisher |
Ito S, Araya J, Kurita Y, Kobayashi K, Takasaka N, Yoshida M, et al. PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. Autophagy. 2015;11:547-59 pubmed publisher |
Askvig J, Watt J. The MAPK and PI3K pathways mediate CNTF-induced neuronal survival and process outgrowth in hypothalamic organotypic cultures. J Cell Commun Signal. 2015;9:217-31 pubmed publisher |
Dasgupta S, Putluri N, Long W, Zhang B, Wang J, Kaushik A, et al. Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis. J Clin Invest. 2015;125:1174-88 pubmed publisher |
Fields J, Dumaop W, Eleuteri S, Elueteri S, Campos S, Serger E, et al. HIV-1 Tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: implications for HIV-associated neurocognitive disorders. J Neurosci. 2015;35:1921-38 pubmed publisher |
Yang M, Li D, Chang Z, Yang Z, Tian Z, Dong Z. PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness. J Exp Med. 2015;212:253-65 pubmed publisher |
López de Figueroa P, Lotz M, Blanco F, Caramés B. Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes. Arthritis Rheumatol. 2015;67:966-76 pubmed publisher |
Dey Guha I, Alves C, Yeh A, Salony -, Sole X, Darp R, et al. A mechanism for asymmetric cell division resulting in proliferative asynchronicity. Mol Cancer Res. 2015;13:223-30 pubmed publisher |
Ma X, Liu H, Murphy J, Foyil S, Godar R, Abuirqeba H, et al. Regulation of the transcription factor EB-PGC1α axis by beclin-1 controls mitochondrial quality and cardiomyocyte death under stress. Mol Cell Biol. 2015;35:956-76 pubmed publisher |
Rebsamen M, Pochini L, Stasyk T, de Araújo M, Galluccio M, Kandasamy R, et al. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. Nature. 2015;519:477-81 pubmed publisher |
Lee J, Tecedor L, Chen Y, Monteys A, Sowada M, Thompson L, et al. Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes. Neuron. 2015;85:303-15 pubmed publisher |
Bernard M, Dieudé M, Yang B, Hamelin K, Underwood K, Hébert M. Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF. Autophagy. 2014;10:2193-207 pubmed publisher |
Thorne C, Wichaidit C, Coster A, Posner B, Wu L, Altschuler S. GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors. Nat Chem Biol. 2015;11:58-63 pubmed publisher |
Toops K, Tan L, Jiang Z, Radu R, Lakkaraju A. Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium. Mol Biol Cell. 2015;26:1-14 pubmed publisher |
Li C, Zhang E, Sun Y, Lee P, Zhan Y, Guo Y, et al. Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis. PLoS ONE. 2014;9:e104809 pubmed publisher |
Sagnier S, Daussy C, Borel S, Robert Hebmann V, Faure M, Blanchet F, et al. Autophagy restricts HIV-1 infection by selectively degrading Tat in CD4+ T lymphocytes. J Virol. 2015;89:615-25 pubmed publisher |
Liang N, Zhang C, Dill P, Panasyuk G, Pion D, Koka V, et al. Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. J Exp Med. 2014;211:2249-63 pubmed publisher |
Sobol A, Galluzzo P, Liang S, Rambo B, Skucha S, Weber M, et al. Amyloid precursor protein (APP) affects global protein synthesis in dividing human cells. J Cell Physiol. 2015;230:1064-74 pubmed publisher |
Sharma M, Bhattacharyya S, Nain M, Kaur M, Sood V, Gupta V, et al. Japanese encephalitis virus replication is negatively regulated by autophagy and occurs on LC3-I- and EDEM1-containing membranes. Autophagy. 2014;10:1637-51 pubmed publisher |
Su M, Huang Y, Chen I, Lee D, Hsieh Y, Li C, et al. An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway. PLoS Pathog. 2014;10:e1004196 pubmed publisher |
Zaccara S, Tebaldi T, Pederiva C, Ciribilli Y, Bisio A, Inga A. p53-directed translational control can shape and expand the universe of p53 target genes. Cell Death Differ. 2014;21:1522-34 pubmed publisher |
Yamamoto A, Mizushima N, Tsukamoto S. Fertilization-induced autophagy in mouse embryos is independent of mTORC1. Biol Reprod. 2014;91:7 pubmed publisher |
Hatanaka M, Maier B, Sims E, Templin A, Kulkarni R, Evans Molina C, et al. Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of rapamycin pathway. Diabetes. 2014;63:3404-15 pubmed publisher |
Zhang J, Wang J, Ng S, Lin Q, Shen H. Development of a novel method for quantification of autophagic protein degradation by AHA labeling. Autophagy. 2014;10:901-12 pubmed publisher |
Zullo A, Jurcic Smith K, Lee S. Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages. BMC Biochem. 2014;15:4 pubmed publisher |
Martina J, Diab H, Lishu L, Jeong A L, Patange S, Raben N, et al. The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris. Sci Signal. 2014;7:ra9 pubmed publisher |
Li C, Lee P, Sun Y, Gu X, Zhang E, Guo Y, et al. Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells. J Exp Med. 2014;211:15-28 pubmed publisher |
Sahani M, Itakura E, Mizushima N. Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids. Autophagy. 2014;10:431-41 pubmed publisher |
Morita M, Gravel S, Chénard V, Sikström K, Zheng L, Alain T, et al. mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metab. 2013;18:698-711 pubmed publisher |
Francipane M, Lagasse E. Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1. Oncotarget. 2013;4:1948-62 pubmed |
Li M, Khambu B, Zhang H, Kang J, Chen X, Chen D, et al. Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity. J Biol Chem. 2013;288:35769-80 pubmed publisher |
Valvezan A, Huang J, Lengner C, Pack M, Klein P. Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish. Dis Model Mech. 2014;7:63-71 pubmed publisher |
Krajcovic M, Krishna S, Akkari L, Joyce J, Overholtzer M. mTOR regulates phagosome and entotic vacuole fission. Mol Biol Cell. 2013;24:3736-45 pubmed publisher |
Montané M, Menand B. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change. J Exp Bot. 2013;64:4361-74 pubmed publisher |
Artal Martinez de Narvajas A, Gomez T, Zhang J, Mann A, Taoda Y, Gorman J, et al. Epigenetic regulation of autophagy by the methyltransferase G9a. Mol Cell Biol. 2013;33:3983-93 pubmed publisher |
Xu Y, Yuan J, Lipinski M. Live imaging and single-cell analysis reveal differential dynamics of autophagy and apoptosis. Autophagy. 2013;9:1418-30 pubmed publisher |
Esen E, Chen J, Karner C, Okunade A, Patterson B, Long F. WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation. Cell Metab. 2013;17:745-55 pubmed publisher |
Fournier M, Coudert L, Mellaoui S, Adjibade P, Gareau C, Côté M, et al. Inactivation of the mTORC1-eukaryotic translation initiation factor 4E pathway alters stress granule formation. Mol Cell Biol. 2013;33:2285-301 pubmed publisher |
Carnevale J, Ross L, Puissant A, Banerji V, Stone R, DeAngelo D, et al. SYK regulates mTOR signaling in AML. Leukemia. 2013;27:2118-28 pubmed publisher |
Kok B, Dyck J, Harris T, Brindley D. Differential regulation of the expressions of the PGC-1? splice variants, lipins, and PPAR? in heart compared to liver. J Lipid Res. 2013;54:1662-77 pubmed publisher |
Martina J, Puertollano R. Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes. J Cell Biol. 2013;200:475-91 pubmed publisher |
Dai N, Christiansen J, Nielsen F, Avruch J. mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts. Genes Dev. 2013;27:301-12 pubmed publisher |
Zhou J, Tan S, Nicolas V, Bauvy C, Yang N, Zhang J, et al. Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion. Cell Res. 2013;23:508-23 pubmed publisher |
Bachar Wikstrom E, Wikstrom J, Ariav Y, Tirosh B, Kaiser N, Cerasi E, et al. Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes. Diabetes. 2013;62:1227-37 pubmed publisher |
Gammoh N, Florey O, Overholtzer M, Jiang X. Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy. Nat Struct Mol Biol. 2013;20:144-9 pubmed publisher |
Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, et al. Keap1 degradation by autophagy for the maintenance of redox homeostasis. Proc Natl Acad Sci U S A. 2012;109:13561-6 pubmed publisher |
Martina J, Chen Y, Gucek M, Puertollano R. MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB. Autophagy. 2012;8:903-14 pubmed publisher |
Fonseca B, Diering G, Bidinosti M, Dalal K, Alain T, Balgi A, et al. Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling. J Biol Chem. 2012;287:17530-45 pubmed publisher |
Thoreen C, Kang S, Chang J, Liu Q, Zhang J, Gao Y, et al. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem. 2009;284:8023-32 pubmed publisher |
