Meclizine dihydrochloride | Tocris Bioscience 4245/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Meclizine dihydrochloride

catalog :

4245/50

quantity :

50 mg

price :

131 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Oosterveen T, Garção P, Moles Garcia E, Soleilhavoup C, Travaglio M, Sheraz S, et al. Pluripotent stem cell derived dopaminergic subpopulations model the selective neuron degeneration in Parkinson's disease. Stem Cell Reports. 2021;16:2718-2735 pubmed publisher
Hong C, Chau K, Schapira A. Meclizine-induced enhanced glycolysis is neuroprotective in Parkinson disease cell models. Sci Rep. 2016;6:25344 pubmed publisher

product information

brand :

Tocris

MasterCode :

4245

SKU :

4245/50

product name :

Meclizine dihydrochloride

target :

Pregnane X Receptor Agonists

category :

Small Molecules

unit size :

50 mg

purity :

99%

observed molecular weight :

463.87

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Meclizine dihydrochloride is a human pregnane X receptor (hPXR) agonist; it is a more potent activator of hPXR than rat PXR. Meclizine increases hPXR target gene expression in human hepatocyte primary cultures. It also acts as a histamine H1 receptor antagonist. Meclizine attenuates mitochondrial respiration and increases glycolysis. The product inhibits rotenone-induced cell death in stem cell-derived dopaminergic neuronal culture and confers neuroprotection in models of polyglutamine (polyQ) toxicity.

extended description :

Human pregnane X receptor agonist; H1 antagonist

chemical name text :

1-[(4-Chlorophenyl)phenylmethyl]4-[(3-methylphenyl)methyl]piperazine dihydrochloride

formula :

C 25 H 27 ClN 2 .2HCl

formula text :

C25H27ClN2.2HCl

cas num :

1104-22-9

USD :

131 USD

product details :

Human pregnane X receptor agonist; H1 antagonist

alt names :

Meclozine

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage