PF 184 | Tocris Bioscience 4238/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 184

catalog :

4238/10

quantity :

10 mg

price :

411 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Harrold A, Cleary M, Bharathy N, Lathara M, Berlow N, Foreman N, et al. In vitro benchmarking of NF-κB inhibitors. Eur J Pharmacol. 2020;873:172981 pubmed publisher
Aarreberg L, Esser Nobis K, Driscoll C, Shuvarikov A, Roby J, Gale M. Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING. Mol Cell. 2019;74:801-815.e6 pubmed publisher
Mora E, Guglielmotti A, Biondi G, Sassone Corsi P. Bindarit: an anti-inflammatory small molecule that modulates the NF?B pathway. Cell Cycle. 2012;11:159-69 pubmed publisher

product information

brand :

Tocris

MasterCode :

4238

SKU :

4238/10

product name :

PF 184

target :

IkB Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

619.09

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PF 184 is a potent and selective IKK inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1 -induced TNF- production in a steroid-insensitive in vitro model of oxidative stress.

extended description :

Potent and selective IKK inhibitor

chemical name text :

8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide

formula :

C 32 H 32 ClFN 6 O 4

formula text :

C32H32ClFN6O4

cas num :

1187460-81-6

USD :

411 USD

product details :

Potent and selective IKK inhibitor

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage